Insider Trades - GEARY RICHARD S

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GEARY RICHARD S: Declared Holdings
Company/Relationship	Reported	Shares	Ownership
Isis Pharmaceuticals, Inc. Officer NasdaqGS:ISIS (historical quotes, profile, other insiders)	19-Apr-13	4,254	Direct

Insider & restricted shareholder transactions reported over the last two years
Date Shares Stock Transaction
19-Apr-13 2,042 ISIS Option Exercise at $11.12 per share.
(Cost of $22,707)
19-Apr-13 2,042 ISIS Automatic Sale at $20.80 per share.
(Proceeds of $42,473)
11-Apr-13 7,000 ISIS Automatic Sale at $19.52 per share.
(Proceeds of $136,640)
11-Apr-13 7,000 ISIS Option Exercise at $11.12 per share.
(Cost of $77,840)
21-Mar-13 1,000 ISIS Automatic Sale at $19.50 per share.
(Proceeds of $19,500)
21-Mar-13 1,000 ISIS Option Exercise at $11.12 per share.
(Cost of $11,120)
16-Jan-13 345 ISIS Sale at $14 per share.
(Proceeds of $4,830)
15-Jan-13 776 ISIS Option Exercise at $0 per share.
3-Jan-13 265 ISIS Automatic Sale at $10.84 per share.
(Proceeds of $2,872)
1-Jan-13 898 ISIS Acquisition (Non Open Market) at $8.87 per share.
(Value of $7,965)
13-Dec-12 6,000 ISIS Automatic Sale at $9.63 per share.
(Proceeds of $57,780)
13-Dec-12 6,000 ISIS Option Exercise at $5.25 per share.
(Cost of $31,500)
9-Jul-12 5,686 ISIS Automatic Sale at $13.45 - $13.49 per share.
(Proceeds of about $77,000)
9-Jul-12 5,686 ISIS Option Exercise at $5.25 per share.
(Cost of $29,851)
3-Jul-12 2,434 ISIS Automatic Sale at $12.91 per share.
(Proceeds of $31,422)
1-Jul-12 1,300 ISIS Acquisition (Non Open Market) at $6.13 per share.
(Value of $7,969)
14-Jun-12 1,579 ISIS Automatic Sale at $10.86 per share.
(Proceeds of $17,147)
1-Jan-12 1,625 ISIS Acquisition (Non Open Market) at $6.13 per share.
(Value of $9,961)
21-Dec-11 1,144 ISIS Automatic Sale at $6.92 per share.
(Proceeds of $7,916)
21-Dec-11 1,144 ISIS Option Exercise at $5.80 per share.
(Cost of $6,635)
20-Dec-11 1,800 ISIS Option Exercise at $5.80 per share.
(Cost of $10,440)
20-Dec-11 1,800 ISIS Automatic Sale at $6.82 - $6.92 per share.
(Proceeds of about $12,000)
19-Dec-11 1,100 ISIS Option Exercise at $5.80 per share.
(Cost of $6,380)
19-Dec-11 1,100 ISIS Automatic Sale at $6.82 - $6.9 per share.
(Proceeds of about $7,546)
16-Dec-11 1,000 ISIS Option Exercise at $5.80 per share.
(Cost of $5,800)
16-Dec-11 1,000 ISIS Automatic Sale at $6.79 per share.
(Proceeds of $6,790)
1-Jul-11 265 ISIS Acquisition (Non Open Market) at $7.91 per share.
(Value of $2,096)

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Insider & restricted shareholder transactions reported over the last two years
Date	Shares	Stock	Transaction
19-Apr-13	2,042	ISIS	Option Exercise at $11.12 per share. (Cost of $22,707)
19-Apr-13	2,042	ISIS	Automatic Sale at $20.80 per share. (Proceeds of $42,473)
11-Apr-13	7,000	ISIS	Automatic Sale at $19.52 per share. (Proceeds of $136,640)
11-Apr-13	7,000	ISIS	Option Exercise at $11.12 per share. (Cost of $77,840)
21-Mar-13	1,000	ISIS	Automatic Sale at $19.50 per share. (Proceeds of $19,500)
21-Mar-13	1,000	ISIS	Option Exercise at $11.12 per share. (Cost of $11,120)
16-Jan-13	345	ISIS	Sale at $14 per share. (Proceeds of $4,830)
15-Jan-13	776	ISIS	Option Exercise at $0 per share.
3-Jan-13	265	ISIS	Automatic Sale at $10.84 per share. (Proceeds of $2,872)
1-Jan-13	898	ISIS	Acquisition (Non Open Market) at $8.87 per share. (Value of $7,965)
13-Dec-12	6,000	ISIS	Automatic Sale at $9.63 per share. (Proceeds of $57,780)
13-Dec-12	6,000	ISIS	Option Exercise at $5.25 per share. (Cost of $31,500)
9-Jul-12	5,686	ISIS	Automatic Sale at $13.45 - $13.49 per share. (Proceeds of about $77,000)
9-Jul-12	5,686	ISIS	Option Exercise at $5.25 per share. (Cost of $29,851)
3-Jul-12	2,434	ISIS	Automatic Sale at $12.91 per share. (Proceeds of $31,422)
1-Jul-12	1,300	ISIS	Acquisition (Non Open Market) at $6.13 per share. (Value of $7,969)
14-Jun-12	1,579	ISIS	Automatic Sale at $10.86 per share. (Proceeds of $17,147)
1-Jan-12	1,625	ISIS	Acquisition (Non Open Market) at $6.13 per share. (Value of $9,961)
21-Dec-11	1,144	ISIS	Automatic Sale at $6.92 per share. (Proceeds of $7,916)
21-Dec-11	1,144	ISIS	Option Exercise at $5.80 per share. (Cost of $6,635)
20-Dec-11	1,800	ISIS	Option Exercise at $5.80 per share. (Cost of $10,440)
20-Dec-11	1,800	ISIS	Automatic Sale at $6.82 - $6.92 per share. (Proceeds of about $12,000)
19-Dec-11	1,100	ISIS	Option Exercise at $5.80 per share. (Cost of $6,380)
19-Dec-11	1,100	ISIS	Automatic Sale at $6.82 - $6.9 per share. (Proceeds of about $7,546)
16-Dec-11	1,000	ISIS	Option Exercise at $5.80 per share. (Cost of $5,800)
16-Dec-11	1,000	ISIS	Automatic Sale at $6.79 per share. (Proceeds of $6,790)
1-Jul-11	265	ISIS	Acquisition (Non Open Market) at $7.91 per share. (Value of $2,096)