Insider Trades - MONIA BRETT P

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MONIA BRETT P: Declared Holdings
Company/Relationship	Reported	Shares	Ownership
Isis Pharmaceuticals, Inc. Officer NasdaqGS:ISIS (historical quotes, profile, other insiders)	22-Apr-13	5,695	Direct

Insider & restricted shareholder transactions reported over the last two years
Date Shares Stock Transaction
22-Apr-13 17,000 ISIS Option Exercise at $11.12 per share.
(Cost of $189,040)
22-Apr-13 17,000 ISIS Automatic Sale at $21.26 per share.
(Proceeds of $361,420)
19-Apr-13 2,500 ISIS Option Exercise at $11.12 per share.
(Cost of $27,799)
19-Apr-13 2,500 ISIS Automatic Sale at $21.25 per share.
(Proceeds of $53,125)
5-Mar-13 18,240 ISIS Automatic Sale at $16.86 per share.
(Proceeds of $307,526)
5-Mar-13 18,240 ISIS Option Exercise at $6.81 per share.
(Cost of $124,214)
16-Jan-13 330 ISIS Sale at $14 per share.
(Proceeds of $4,620)
15-Jan-13 737 ISIS Option Exercise at $0 per share.
3-Jan-13 311 ISIS Automatic Sale at $10.84 per share.
(Proceeds of $3,371)
1-Jan-13 215 ISIS Acquisition (Non Open Market) at $8.87 per share.
(Value of $1,907)
6-Sep-12 12,031 ISIS Automatic Sale at $15.25 per share.
(Proceeds of $183,472)
6-Sep-12 12,031 ISIS Option Exercise at $5.25 per share.
(Cost of $63,162)
3-Jul-12 587 ISIS Automatic Sale at $12.92 per share.
(Proceeds of $7,584)
1-Jul-12 311 ISIS Acquisition (Non Open Market) at $6.13 per share.
(Value of $1,906)
1-Jan-12 587 ISIS Disposition (Non Open Market) at $6.13 per share.
(Value of $3,598)
1-Dec-11 5,073 ISIS Statement of Ownership

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Insider & restricted shareholder transactions reported over the last two years
Date	Shares	Stock	Transaction
22-Apr-13	17,000	ISIS	Option Exercise at $11.12 per share. (Cost of $189,040)
22-Apr-13	17,000	ISIS	Automatic Sale at $21.26 per share. (Proceeds of $361,420)
19-Apr-13	2,500	ISIS	Option Exercise at $11.12 per share. (Cost of $27,799)
19-Apr-13	2,500	ISIS	Automatic Sale at $21.25 per share. (Proceeds of $53,125)
5-Mar-13	18,240	ISIS	Automatic Sale at $16.86 per share. (Proceeds of $307,526)
5-Mar-13	18,240	ISIS	Option Exercise at $6.81 per share. (Cost of $124,214)
16-Jan-13	330	ISIS	Sale at $14 per share. (Proceeds of $4,620)
15-Jan-13	737	ISIS	Option Exercise at $0 per share.
3-Jan-13	311	ISIS	Automatic Sale at $10.84 per share. (Proceeds of $3,371)
1-Jan-13	215	ISIS	Acquisition (Non Open Market) at $8.87 per share. (Value of $1,907)
6-Sep-12	12,031	ISIS	Automatic Sale at $15.25 per share. (Proceeds of $183,472)
6-Sep-12	12,031	ISIS	Option Exercise at $5.25 per share. (Cost of $63,162)
3-Jul-12	587	ISIS	Automatic Sale at $12.92 per share. (Proceeds of $7,584)
1-Jul-12	311	ISIS	Acquisition (Non Open Market) at $6.13 per share. (Value of $1,906)
1-Jan-12	587	ISIS	Disposition (Non Open Market) at $6.13 per share. (Value of $3,598)
1-Dec-11	5,073	ISIS	Statement of Ownership