Insider Trades - ECKER DAVID J

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ECKER DAVID J: Declared Holdings
Company/Relationship	Reported	Shares	Ownership
Isis Pharmaceuticals, Inc. Officer NasdaqGM:ISIS (historical quotes, profile, other insiders)	2-Sep-08 19-May-08	0 28,713 28,713	Direct Indirect Total

Insider & restricted shareholder transactions reported over the last two years
Date Shares Stock Transaction
2-Sep-08 10,000 ISIS Option Exercise at $6.81 per share.
(Cost of $68,100)
2-Sep-08 10,000 ISIS Automatic Sale at $18.11 per share.
(Proceeds of $181,100)
22-Aug-08 10,000 ISIS Option Exercise at $6.81 per share.
(Cost of $68,100)
22-Aug-08 10,000 ISIS Automatic Sale at $18.04 per share.
(Proceeds of $180,400)
11-Aug-08 15,000 ISIS Option Exercise at $5.80 per share.
(Cost of $87,000)
11-Aug-08 15,000 ISIS Automatic Sale at $18.03 - $18.55 per share.
(Proceeds of about $274,000)
19-May-08 *1,500 ISIS Disposition (Non Open Market) at $0 per share.
10-Apr-08 5,300 ISIS Option Exercise at $6.84 per share.
(Cost of $36,252)
10-Apr-08 5,300 ISIS Automatic Sale at $16.04 per share.
(Proceeds of $85,012)
7-Apr-08 12,200 ISIS Option Exercise at $5.80 - $6.84 per share.
(Cost of about $77,000)
7-Apr-08 12,200 ISIS Automatic Sale at $16.03 - $16.08 per share.
(Proceeds of about $196,000)
4-Jan-08 *3,000 ISIS Disposition (Non Open Market) at $0 per share.
1-Jan-08 *2,065 ISIS Acquisition (Non Open Market) at $8.30 per share.
(Value of $17,139)
* Indicates that some (or all) shares are held indirectly (e.g. in a trust, by a spouse, etc.)

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Insider & restricted shareholder transactions reported over the last two years
Date	Shares	Stock	Transaction
2-Sep-08	10,000	ISIS	Option Exercise at $6.81 per share. (Cost of $68,100)
2-Sep-08	10,000	ISIS	Automatic Sale at $18.11 per share. (Proceeds of $181,100)
22-Aug-08	10,000	ISIS	Option Exercise at $6.81 per share. (Cost of $68,100)
22-Aug-08	10,000	ISIS	Automatic Sale at $18.04 per share. (Proceeds of $180,400)
11-Aug-08	15,000	ISIS	Option Exercise at $5.80 per share. (Cost of $87,000)
11-Aug-08	15,000	ISIS	Automatic Sale at $18.03 - $18.55 per share. (Proceeds of about $274,000)
19-May-08	*1,500	ISIS	Disposition (Non Open Market) at $0 per share.
10-Apr-08	5,300	ISIS	Option Exercise at $6.84 per share. (Cost of $36,252)
10-Apr-08	5,300	ISIS	Automatic Sale at $16.04 per share. (Proceeds of $85,012)
7-Apr-08	12,200	ISIS	Option Exercise at $5.80 - $6.84 per share. (Cost of about $77,000)
7-Apr-08	12,200	ISIS	Automatic Sale at $16.03 - $16.08 per share. (Proceeds of about $196,000)
4-Jan-08	*3,000	ISIS	Disposition (Non Open Market) at $0 per share.
1-Jan-08	*2,065	ISIS	Acquisition (Non Open Market) at $8.30 per share. (Value of $17,139)