Insider Trades - ORBIMED ADVISORS LLC

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ORBIMED ADVISORS LLC: Declared Holdings
Company/Relationship	Reported	Shares	Ownership
Ambit Biosciences Corporation Beneficial Owner (10% or more) NasdaqGM:AMBI (historical quotes, profile, other insiders)	21-May-13	1,443,222	Indirect
Amarin Corporation plc Director NasdaqGM:AMRN (historical quotes, profile, other insiders)	4-Sep-12	5,700	Indirect
Anthera Pharmaceuticals, Inc. Director NasdaqGM:ANTH (historical quotes, profile, other insiders)	30-Jan-13	7,462,000	Indirect
ChemoCentryx, Inc. Beneficial Owner (10% or more) NasdaqGS:CCXI (historical quotes, profile, other insiders)	13-Feb-12	2,201,388	Indirect
Pacira Pharmaceuticals, Inc. Beneficial Owner (10% or more) NasdaqGS:PCRX (historical quotes, profile, other insiders)	12-Mar-12	2,446,000	Indirect
Supernus Pharmaceuticals, Inc. Beneficial Owner (10% or more) NasdaqGM:SUPN (historical quotes, profile, other insiders)	13-Feb-13	817,000	Indirect

Insider & restricted shareholder transactions reported over the last two years
Date Shares Stock Transaction
21-May-13 *669,871 AMBI Purchase at $6.90 - $8 per share.
(Cost of about $4,991,000)
21-May-13 *776,189 AMBI Acquisition (Non Open Market)
20-May-13 *10,600 AMBI Purchase at $6.78 per share.
(Cost of $71,868)
15-May-13 *307 AMBI Statement of Ownership
13-Feb-13 *150,000 SUPN Sale at $7.58 per share.
(Proceeds of $1,137,000)
12-Feb-13 *152,183 SUPN Sale at $7.52 per share.
(Proceeds of $1,144,416)
30-Jan-13 *5,700,000 ANTH Purchase at $0.66 per share.
(Cost of $3,762,000)
25-Jan-13 *1,762,000 ANTH Purchase at $0.65 per share.
(Cost of $1,145,300)
18-Dec-12 *100,000 SUPN Sale at $7.08 per share.
(Proceeds of $708,000)
17-Dec-12 *197,815 SUPN Sale at $6.85 per share.
(Proceeds of $1,355,032)
4-Sep-12 *233,700 AMRN Automatic Sale at $14.43 per share.
(Proceeds of $3,372,291)
27-Jul-12 *366,300 AMRN Automatic Sale at $14.61 per share.
(Proceeds of $5,351,643)
29-Jun-12 *1,283,300 ANTH Sale at $0.73 per share.
(Proceeds of $936,809)
19-Jun-12 *617,100 AMRN Sale at $12.91 per share.
(Proceeds of $7,966,761)
4-May-12 *1,100,000 SUPN Purchase at $5 per share.
(Cost of $5,500,000)
4-May-12 *2,499,998 SUPN Acquisition (Non Open Market)
22-Mar-12 *1,306,700 ANTH Sale at $2.40 per share.
(Proceeds of $3,136,080)
21-Mar-12 *125,000 ANTH Sale at $2.87 per share.
(Proceeds of $358,750)
20-Mar-12 *116,800 ANTH Sale at $2.90 per share.
(Proceeds of $338,720)
12-Mar-12 *63,100 PCRX Sale at $11.03 per share.
(Proceeds of $695,993)
9-Mar-12 *37,000 PCRX Sale at $11.25 per share.
(Proceeds of $416,250)
29-Feb-12 *3,000 PCRX Sale at $10.86 per share.
(Proceeds of $32,580)
28-Feb-12 *10,100 PCRX Sale at $11.12 per share.
(Proceeds of $112,311)
27-Feb-12 *29,000 PCRX Sale at $11.05 per share.
(Proceeds of $320,450)
13-Feb-12 *3,154,714 CCXI Acquisition (Non Open Market)
3-Feb-12 *50,000 PCRX Sale at $10.79 per share.
(Proceeds of $539,500)
2-Feb-12 *23,300 PCRX Sale at $10.85 per share.
(Proceeds of $252,805)
1-Feb-12 *70,000 PCRX Sale at $11.01 per share.
(Proceeds of $770,700)
13-Dec-11 *16,200 ANTH Sale at $6.50 per share.
(Proceeds of $105,300)
9-Dec-11 *40,000 ANTH Sale at $6.75 per share.
(Proceeds of $270,000)
18-Nov-11 *3,000 ANTH Sale at $6.50 per share.
(Proceeds of $19,500)
17-Nov-11 *24,000 ANTH Sale at $6.67 per share.
(Proceeds of $160,080)
16-Nov-11 *25,000 ANTH Sale at $6.87 per share.
(Proceeds of $171,750)
15-Nov-11 *50,000 ANTH Sale at $6.93 per share.
(Proceeds of $346,500)
14-Nov-11 *5,000 ANTH Sale at $6.95 per share.
(Proceeds of $34,750)
11-Nov-11 *5,000 ANTH Sale at $7.14 per share.
(Proceeds of $35,700)
31-Oct-11 *97,441 PCRX Sale at $10.53 per share.
(Proceeds of $1,026,053)
10-Jun-11 *30,000 ANTH Sale at $8.18 per share.
(Proceeds of $245,400)
9-Jun-11 *37,000 ANTH Sale at $8.11 per share.
(Proceeds of $300,070)
8-Jun-11 *33,000 ANTH Sale at $8.02 per share.
(Proceeds of $264,660)
26-May-11 *34,200 ANTH Sale at $8.53 per share.
(Proceeds of $291,726)
25-May-11 *4,800 ANTH Sale at $8.65 per share.
(Proceeds of $41,520)
* Indicates that some (or all) shares are held indirectly (e.g. in a trust, by a spouse, etc.)

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Insider & restricted shareholder transactions reported over the last two years
Date	Shares	Stock	Transaction
21-May-13	*669,871	AMBI	Purchase at $6.90 - $8 per share. (Cost of about $4,991,000)
21-May-13	*776,189	AMBI	Acquisition (Non Open Market)
20-May-13	*10,600	AMBI	Purchase at $6.78 per share. (Cost of $71,868)
15-May-13	*307	AMBI	Statement of Ownership
13-Feb-13	*150,000	SUPN	Sale at $7.58 per share. (Proceeds of $1,137,000)
12-Feb-13	*152,183	SUPN	Sale at $7.52 per share. (Proceeds of $1,144,416)
30-Jan-13	*5,700,000	ANTH	Purchase at $0.66 per share. (Cost of $3,762,000)
25-Jan-13	*1,762,000	ANTH	Purchase at $0.65 per share. (Cost of $1,145,300)
18-Dec-12	*100,000	SUPN	Sale at $7.08 per share. (Proceeds of $708,000)
17-Dec-12	*197,815	SUPN	Sale at $6.85 per share. (Proceeds of $1,355,032)
4-Sep-12	*233,700	AMRN	Automatic Sale at $14.43 per share. (Proceeds of $3,372,291)
27-Jul-12	*366,300	AMRN	Automatic Sale at $14.61 per share. (Proceeds of $5,351,643)
29-Jun-12	*1,283,300	ANTH	Sale at $0.73 per share. (Proceeds of $936,809)
19-Jun-12	*617,100	AMRN	Sale at $12.91 per share. (Proceeds of $7,966,761)
4-May-12	*1,100,000	SUPN	Purchase at $5 per share. (Cost of $5,500,000)
4-May-12	*2,499,998	SUPN	Acquisition (Non Open Market)
22-Mar-12	*1,306,700	ANTH	Sale at $2.40 per share. (Proceeds of $3,136,080)
21-Mar-12	*125,000	ANTH	Sale at $2.87 per share. (Proceeds of $358,750)
20-Mar-12	*116,800	ANTH	Sale at $2.90 per share. (Proceeds of $338,720)
12-Mar-12	*63,100	PCRX	Sale at $11.03 per share. (Proceeds of $695,993)
9-Mar-12	*37,000	PCRX	Sale at $11.25 per share. (Proceeds of $416,250)
29-Feb-12	*3,000	PCRX	Sale at $10.86 per share. (Proceeds of $32,580)
28-Feb-12	*10,100	PCRX	Sale at $11.12 per share. (Proceeds of $112,311)
27-Feb-12	*29,000	PCRX	Sale at $11.05 per share. (Proceeds of $320,450)
13-Feb-12	*3,154,714	CCXI	Acquisition (Non Open Market)
3-Feb-12	*50,000	PCRX	Sale at $10.79 per share. (Proceeds of $539,500)
2-Feb-12	*23,300	PCRX	Sale at $10.85 per share. (Proceeds of $252,805)
1-Feb-12	*70,000	PCRX	Sale at $11.01 per share. (Proceeds of $770,700)
13-Dec-11	*16,200	ANTH	Sale at $6.50 per share. (Proceeds of $105,300)
9-Dec-11	*40,000	ANTH	Sale at $6.75 per share. (Proceeds of $270,000)
18-Nov-11	*3,000	ANTH	Sale at $6.50 per share. (Proceeds of $19,500)
17-Nov-11	*24,000	ANTH	Sale at $6.67 per share. (Proceeds of $160,080)
16-Nov-11	*25,000	ANTH	Sale at $6.87 per share. (Proceeds of $171,750)
15-Nov-11	*50,000	ANTH	Sale at $6.93 per share. (Proceeds of $346,500)
14-Nov-11	*5,000	ANTH	Sale at $6.95 per share. (Proceeds of $34,750)
11-Nov-11	*5,000	ANTH	Sale at $7.14 per share. (Proceeds of $35,700)
31-Oct-11	*97,441	PCRX	Sale at $10.53 per share. (Proceeds of $1,026,053)
10-Jun-11	*30,000	ANTH	Sale at $8.18 per share. (Proceeds of $245,400)
9-Jun-11	*37,000	ANTH	Sale at $8.11 per share. (Proceeds of $300,070)
8-Jun-11	*33,000	ANTH	Sale at $8.02 per share. (Proceeds of $264,660)
26-May-11	*34,200	ANTH	Sale at $8.53 per share. (Proceeds of $291,726)
25-May-11	*4,800	ANTH	Sale at $8.65 per share. (Proceeds of $41,520)