Insider Trades - BENNETT C FRANK

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BENNETT C FRANK: Declared Holdings
Company/Relationship	Reported	Shares	Ownership
ISIS PHARM INC Officer NasdaqGM:ISIS (historical quotes, profile, other insiders)	20-Aug-08	537	Direct

Insider & restricted shareholder transactions reported over the last two years
Date Shares Stock Transaction
20-Aug-08 6,000 ISIS Option Exercise at $6.81 per share.
(Cost of $40,860)
20-Aug-08 6,000 ISIS Automatic Sale at $17.97 per share.
(Proceeds of $107,820)
15-Aug-08 1,000 ISIS Option Exercise at $6.25 per share.
(Cost of $6,250)
15-Aug-08 1,000 ISIS Automatic Sale at $19.25 per share.
(Proceeds of $19,250)
14-Aug-08 7,000 ISIS Option Exercise at $6.25 per share.
(Cost of $43,750)
14-Aug-08 7,000 ISIS Automatic Sale at $19.26 per share.
(Proceeds of $134,820)
11-Aug-08 15,000 ISIS Option Exercise at $12.94 per share.
(Cost of $194,100)
11-Aug-08 15,000 ISIS Automatic Sale at $18.03 - $18.52 per share.
(Proceeds of about $274,000)
1-Jul-08 145 ISIS Acquisition (Non Open Market) at $11.80 per share.
(Value of $1,711)
1-Apr-08 10,000 ISIS Option Exercise at $5.25 per share.
(Cost of $52,500)
1-Apr-08 10,000 ISIS Automatic Sale at $15.33 per share.
(Proceeds of $153,300)
1-Jan-08 195 ISIS Acquisition (Non Open Market) at $8.30 per share.
(Value of $1,618)
20-Sep-07 14,000 ISIS Option Exercise at $12.31 - $12.31 per share.
(Cost of about $172,000)
20-Sep-07 14,000 ISIS Automatic Sale at $14.76 per share.
(Proceeds of $206,640)
14-Sep-07 10,000 ISIS Option Exercise at $5.15 - $5.15 per share.
(Cost of about $52,000)
14-Sep-07 10,000 ISIS Automatic Sale at $13.76 - $13.76 per share.
(Proceeds of about $138,000)
21-Aug-07 10,000 ISIS Option Exercise at $6.25 - $6.25 per share.
(Cost of about $63,000)
21-Aug-07 10,000 ISIS Automatic Sale at $12.50 - $12.5 per share.
(Proceeds of about $125,000)
9-Jul-07 4,599 ISIS Option Exercise at $5.15 - $5.15 per share.
(Cost of about $24,000)
9-Jul-07 5,732 ISIS Automatic Sale at $10.57 - $11 per share.
(Proceeds of about $62,000)
1-Jul-07 197 ISIS Acquisition (Non Open Market) at $8.23 - $8.23 per share.
(Value of about $1,621)
1-Jan-07 302 ISIS Acquisition (Non Open Market) at $5.14 - $5.14 per share.
(Value of about $1,552)
13-Nov-06 10,000 ISIS Option Exercise at $5.15 - $5.15 per share.
(Cost of about $52,000)
13-Nov-06 10,000 ISIS Automatic Sale at $13.36 - $13.36 per share.
(Proceeds of about $134,000)
9-Nov-06 10,000 ISIS Option Exercise at $5.15 - $5.15 per share.
(Cost of about $52,000)
9-Nov-06 10,000 ISIS Automatic Sale at $10.13 - $10.13 per share.
(Proceeds of about $101,000)

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Insider & restricted shareholder transactions reported over the last two years
Date	Shares	Stock	Transaction
20-Aug-08	6,000	ISIS	Option Exercise at $6.81 per share. (Cost of $40,860)
20-Aug-08	6,000	ISIS	Automatic Sale at $17.97 per share. (Proceeds of $107,820)
15-Aug-08	1,000	ISIS	Option Exercise at $6.25 per share. (Cost of $6,250)
15-Aug-08	1,000	ISIS	Automatic Sale at $19.25 per share. (Proceeds of $19,250)
14-Aug-08	7,000	ISIS	Option Exercise at $6.25 per share. (Cost of $43,750)
14-Aug-08	7,000	ISIS	Automatic Sale at $19.26 per share. (Proceeds of $134,820)
11-Aug-08	15,000	ISIS	Option Exercise at $12.94 per share. (Cost of $194,100)
11-Aug-08	15,000	ISIS	Automatic Sale at $18.03 - $18.52 per share. (Proceeds of about $274,000)
1-Jul-08	145	ISIS	Acquisition (Non Open Market) at $11.80 per share. (Value of $1,711)
1-Apr-08	10,000	ISIS	Option Exercise at $5.25 per share. (Cost of $52,500)
1-Apr-08	10,000	ISIS	Automatic Sale at $15.33 per share. (Proceeds of $153,300)
1-Jan-08	195	ISIS	Acquisition (Non Open Market) at $8.30 per share. (Value of $1,618)
20-Sep-07	14,000	ISIS	Option Exercise at $12.31 - $12.31 per share. (Cost of about $172,000)
20-Sep-07	14,000	ISIS	Automatic Sale at $14.76 per share. (Proceeds of $206,640)
14-Sep-07	10,000	ISIS	Option Exercise at $5.15 - $5.15 per share. (Cost of about $52,000)
14-Sep-07	10,000	ISIS	Automatic Sale at $13.76 - $13.76 per share. (Proceeds of about $138,000)
21-Aug-07	10,000	ISIS	Option Exercise at $6.25 - $6.25 per share. (Cost of about $63,000)
21-Aug-07	10,000	ISIS	Automatic Sale at $12.50 - $12.5 per share. (Proceeds of about $125,000)
9-Jul-07	4,599	ISIS	Option Exercise at $5.15 - $5.15 per share. (Cost of about $24,000)
9-Jul-07	5,732	ISIS	Automatic Sale at $10.57 - $11 per share. (Proceeds of about $62,000)
1-Jul-07	197	ISIS	Acquisition (Non Open Market) at $8.23 - $8.23 per share. (Value of about $1,621)
1-Jan-07	302	ISIS	Acquisition (Non Open Market) at $5.14 - $5.14 per share. (Value of about $1,552)
13-Nov-06	10,000	ISIS	Option Exercise at $5.15 - $5.15 per share. (Cost of about $52,000)
13-Nov-06	10,000	ISIS	Automatic Sale at $13.36 - $13.36 per share. (Proceeds of about $134,000)
9-Nov-06	10,000	ISIS	Option Exercise at $5.15 - $5.15 per share. (Cost of about $52,000)
9-Nov-06	10,000	ISIS	Automatic Sale at $10.13 - $10.13 per share. (Proceeds of about $101,000)