Insider Trades - BENNETT C FRANK

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BENNETT C FRANK: Declared Holdings
Company/Relationship	Reported	Shares	Ownership
Isis Pharmaceuticals, Inc. Officer NasdaqGS:ISIS (historical quotes, profile, other insiders)	1-May-13	2,110	Direct

Insider & restricted shareholder transactions reported over the last two years
Date Shares Stock Transaction
1-May-13 29,945 ISIS Option Exercise at $6.81 - $11.12 per share.
1-May-13 29,945 ISIS Automatic Sale at $22.26 per share.
(Proceeds of $666,575)
30-Apr-13 30,000 ISIS Option Exercise at $11.12 per share.
(Cost of $333,600)
30-Apr-13 30,000 ISIS Automatic Sale at $22.51 per share.
(Proceeds of $675,300)
16-Jan-13 309 ISIS Sale at $14 per share.
(Proceeds of $4,326)
15-Jan-13 695 ISIS Option Exercise at $0 per share.
1-Jan-13 447 ISIS Acquisition (Non Open Market) at $8.87 per share.
(Value of $3,964)
9-Jul-12 10,500 ISIS Automatic Sale at $13.51 per share.
(Proceeds of $141,855)
9-Jul-12 10,500 ISIS Option Exercise at $6.81 - $6.84 per share.
(Cost of about $72,000)
3-Jul-12 6,000 ISIS Automatic Sale at $12.91 per share.
(Proceeds of $77,460)
3-Jul-12 6,000 ISIS Option Exercise at $6.84 per share.
(Cost of $41,040)
1-Jul-12 648 ISIS Acquisition (Non Open Market) at $6.13 per share.
(Value of $3,972)
21-Dec-11 1,555 ISIS Automatic Sale at $6.92 per share.
(Proceeds of $10,760)
21-Dec-11 1,555 ISIS Option Exercise at $5.80 per share.
(Cost of $9,019)
20-Dec-11 2,500 ISIS Automatic Sale at $6.82 - $6.92 per share.
(Proceeds of about $17,000)
20-Dec-11 2,500 ISIS Option Exercise at $5.80 per share.
(Cost of $14,500)
19-Dec-11 1,500 ISIS Option Exercise at $5.80 per share.
(Cost of $8,700)
19-Dec-11 1,500 ISIS Automatic Sale at $6.82 - $6.9 per share.
(Proceeds of about $10,000)
16-Dec-11 1,500 ISIS Automatic Sale at $6.79 per share.
(Proceeds of $10,185)
16-Dec-11 1,500 ISIS Option Exercise at $5.80 per share.
(Cost of $8,700)
1-Dec-11 324 ISIS Acquisition (Non Open Market) at $6.13 per share.
(Value of $1,986)
4-Aug-11 10,000 ISIS Automatic Sale at $7.62 per share.
(Proceeds of $76,200)
4-Aug-11 10,000 ISIS Option Exercise at $5.25 per share.
(Cost of $52,500)
28-Jul-11 1,000 ISIS Automatic Sale at $8.60 per share.
(Proceeds of $8,600)
1-Jul-11 251 ISIS Acquisition (Non Open Market) at $7.91 per share.
(Value of $1,985)

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Insider & restricted shareholder transactions reported over the last two years
Date	Shares	Stock	Transaction
1-May-13	29,945	ISIS	Option Exercise at $6.81 - $11.12 per share.
1-May-13	29,945	ISIS	Automatic Sale at $22.26 per share. (Proceeds of $666,575)
30-Apr-13	30,000	ISIS	Option Exercise at $11.12 per share. (Cost of $333,600)
30-Apr-13	30,000	ISIS	Automatic Sale at $22.51 per share. (Proceeds of $675,300)
16-Jan-13	309	ISIS	Sale at $14 per share. (Proceeds of $4,326)
15-Jan-13	695	ISIS	Option Exercise at $0 per share.
1-Jan-13	447	ISIS	Acquisition (Non Open Market) at $8.87 per share. (Value of $3,964)
9-Jul-12	10,500	ISIS	Automatic Sale at $13.51 per share. (Proceeds of $141,855)
9-Jul-12	10,500	ISIS	Option Exercise at $6.81 - $6.84 per share. (Cost of about $72,000)
3-Jul-12	6,000	ISIS	Automatic Sale at $12.91 per share. (Proceeds of $77,460)
3-Jul-12	6,000	ISIS	Option Exercise at $6.84 per share. (Cost of $41,040)
1-Jul-12	648	ISIS	Acquisition (Non Open Market) at $6.13 per share. (Value of $3,972)
21-Dec-11	1,555	ISIS	Automatic Sale at $6.92 per share. (Proceeds of $10,760)
21-Dec-11	1,555	ISIS	Option Exercise at $5.80 per share. (Cost of $9,019)
20-Dec-11	2,500	ISIS	Automatic Sale at $6.82 - $6.92 per share. (Proceeds of about $17,000)
20-Dec-11	2,500	ISIS	Option Exercise at $5.80 per share. (Cost of $14,500)
19-Dec-11	1,500	ISIS	Option Exercise at $5.80 per share. (Cost of $8,700)
19-Dec-11	1,500	ISIS	Automatic Sale at $6.82 - $6.9 per share. (Proceeds of about $10,000)
16-Dec-11	1,500	ISIS	Automatic Sale at $6.79 per share. (Proceeds of $10,185)
16-Dec-11	1,500	ISIS	Option Exercise at $5.80 per share. (Cost of $8,700)
1-Dec-11	324	ISIS	Acquisition (Non Open Market) at $6.13 per share. (Value of $1,986)
4-Aug-11	10,000	ISIS	Automatic Sale at $7.62 per share. (Proceeds of $76,200)
4-Aug-11	10,000	ISIS	Option Exercise at $5.25 per share. (Cost of $52,500)
28-Jul-11	1,000	ISIS	Automatic Sale at $8.60 per share. (Proceeds of $8,600)
1-Jul-11	251	ISIS	Acquisition (Non Open Market) at $7.91 per share. (Value of $1,985)