Insider Trades - BENNETT C FRANK

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BENNETT C FRANK: Declared Holdings
Company/Relationship	Reported	Shares	Ownership
Isis Pharmaceuticals, Inc. Officer NasdaqGM:ISIS (historical quotes, profile, other insiders)	23-Jul-09	976	Direct

Insider & restricted shareholder transactions reported over the last two years
Date Shares Stock Transaction
23-Jul-09 12,000 ISIS Option Exercise at $6.81 per share.
(Cost of $81,720)
23-Jul-09 12,000 ISIS Automatic Sale at $17.03 per share.
(Proceeds of $204,360)
1-Jul-09 289 ISIS Acquisition (Non Open Market) at $12.30 per share.
(Value of $3,554)
22-Apr-09 10,000 ISIS Option Exercise at $6.81 per share.
(Cost of $68,100)
22-Apr-09 10,000 ISIS Automatic Sale at $15.92 per share.
(Proceeds of $159,200)
7-Apr-09 10,000 ISIS Option Exercise at $6.81 per share.
(Cost of $68,100)
7-Apr-09 10,000 ISIS Automatic Sale at $14.60 per share.
(Proceeds of $146,000)
1-Jan-09 150 ISIS Acquisition (Non Open Market) at $11.65 per share.
(Value of $1,747)
20-Aug-08 6,000 ISIS Option Exercise at $6.81 per share.
(Cost of $40,860)
20-Aug-08 6,000 ISIS Automatic Sale at $17.97 per share.
(Proceeds of $107,820)
15-Aug-08 1,000 ISIS Option Exercise at $6.25 per share.
(Cost of $6,250)
15-Aug-08 1,000 ISIS Automatic Sale at $19.25 per share.
(Proceeds of $19,250)
14-Aug-08 7,000 ISIS Option Exercise at $6.25 per share.
(Cost of $43,750)
14-Aug-08 7,000 ISIS Automatic Sale at $19.26 per share.
(Proceeds of $134,820)
11-Aug-08 15,000 ISIS Option Exercise at $12.94 per share.
(Cost of $194,100)
11-Aug-08 15,000 ISIS Automatic Sale at $18.03 - $18.52 per share.
(Proceeds of about $274,000)
1-Jul-08 145 ISIS Acquisition (Non Open Market) at $11.80 per share.
(Value of $1,711)
1-Apr-08 10,000 ISIS Option Exercise at $5.25 per share.
(Cost of $52,500)
1-Apr-08 10,000 ISIS Automatic Sale at $15.33 per share.
(Proceeds of $153,300)
1-Jan-08 195 ISIS Acquisition (Non Open Market) at $8.30 per share.
(Value of $1,618)

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Insider & restricted shareholder transactions reported over the last two years
Date	Shares	Stock	Transaction
23-Jul-09	12,000	ISIS	Option Exercise at $6.81 per share. (Cost of $81,720)
23-Jul-09	12,000	ISIS	Automatic Sale at $17.03 per share. (Proceeds of $204,360)
1-Jul-09	289	ISIS	Acquisition (Non Open Market) at $12.30 per share. (Value of $3,554)
22-Apr-09	10,000	ISIS	Option Exercise at $6.81 per share. (Cost of $68,100)
22-Apr-09	10,000	ISIS	Automatic Sale at $15.92 per share. (Proceeds of $159,200)
7-Apr-09	10,000	ISIS	Option Exercise at $6.81 per share. (Cost of $68,100)
7-Apr-09	10,000	ISIS	Automatic Sale at $14.60 per share. (Proceeds of $146,000)
1-Jan-09	150	ISIS	Acquisition (Non Open Market) at $11.65 per share. (Value of $1,747)
20-Aug-08	6,000	ISIS	Option Exercise at $6.81 per share. (Cost of $40,860)
20-Aug-08	6,000	ISIS	Automatic Sale at $17.97 per share. (Proceeds of $107,820)
15-Aug-08	1,000	ISIS	Option Exercise at $6.25 per share. (Cost of $6,250)
15-Aug-08	1,000	ISIS	Automatic Sale at $19.25 per share. (Proceeds of $19,250)
14-Aug-08	7,000	ISIS	Option Exercise at $6.25 per share. (Cost of $43,750)
14-Aug-08	7,000	ISIS	Automatic Sale at $19.26 per share. (Proceeds of $134,820)
11-Aug-08	15,000	ISIS	Option Exercise at $12.94 per share. (Cost of $194,100)
11-Aug-08	15,000	ISIS	Automatic Sale at $18.03 - $18.52 per share. (Proceeds of about $274,000)
1-Jul-08	145	ISIS	Acquisition (Non Open Market) at $11.80 per share. (Value of $1,711)
1-Apr-08	10,000	ISIS	Option Exercise at $5.25 per share. (Cost of $52,500)
1-Apr-08	10,000	ISIS	Automatic Sale at $15.33 per share. (Proceeds of $153,300)
1-Jan-08	195	ISIS	Acquisition (Non Open Market) at $8.30 per share. (Value of $1,618)