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Insider Filings - CROOKE STANLEY T
Last Updated 
26-Nov-09
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CROOKE STANLEY T: Declared Holdings
Company/RelationshipReportedShares  Ownership
Isis Pharmaceuticals, Inc.
Officer
NasdaqGM:ISIS
(historical quotes, profile, other insiders) 		30-Dec-08
23-Dec-08		0
   0
0		  Direct
  Indirect  
  Total

Insider & restricted shareholder transactions reported over the last two years
DateSharesStockTransaction
30-Dec-08 7,500ISIS Option Exercise at $12.94 per share.
(Cost of $97,050)
30-Dec-08 7,500ISIS Automatic Sale at $13.37 per share.
(Proceeds of $100,275)
26-Dec-08 7,500ISIS Option Exercise at $12.94 per share.
(Cost of $97,050)
26-Dec-08 7,500ISIS Automatic Sale at $13.25 per share.
(Proceeds of $99,375)
23-Dec-08 *1,800ISIS Option Exercise at $12.94 per share.
(Cost of $23,292)
23-Dec-08 8,000ISIS Option Exercise at $12.94 per share.
(Cost of $103,520)
23-Dec-08 *1,800ISIS Automatic Sale at $13.52 per share.
(Proceeds of $24,336)
23-Dec-08 8,000ISIS Automatic Sale at $13.52 per share.
(Proceeds of $108,160)
19-Dec-08 *1,000ISIS Option Exercise at $12.94 per share.
(Cost of $12,940)
19-Dec-08 12,000ISIS Option Exercise at $12.94 per share.
(Cost of $155,280)
19-Dec-08 *1,000ISIS Automatic Sale at $13.93 per share.
(Proceeds of $13,930)
19-Dec-08 12,000ISIS Automatic Sale at $13.93 per share.
(Proceeds of $167,160)
17-Dec-08 *4,691ISIS Option Exercise at $5.15 per share.
(Cost of $24,158)
17-Dec-08 7,482ISIS Option Exercise at $5.15 per share.
(Cost of $38,532)
17-Dec-08 *4,691ISIS Automatic Sale at $12.80 per share.
(Proceeds of $60,044)
17-Dec-08 7,482ISIS Automatic Sale at $12.80 per share.
(Proceeds of $95,769)
28-Dec-07 20,000ISIS Option Exercise at $12.31 per share.
(Cost of $246,200)
28-Dec-07 20,000ISIS Automatic Sale at $16.22 per share.
(Proceeds of $324,400)
27-Dec-07 6,000ISIS Option Exercise at $12.31 per share.
(Cost of $73,860)
27-Dec-07 *2,100ISIS Option Exercise at $12.31 per share.
(Cost of $25,851)
27-Dec-07 6,000ISIS Automatic Sale at $16.32 per share.
(Proceeds of $97,920)
26-Dec-07 24,000ISIS Option Exercise at $12.31 per share.
(Cost of $295,440)
26-Dec-07 24,000ISIS Automatic Sale at $16.53 per share.
(Proceeds of $396,720)
11-Dec-07 20,000ISIS Option Exercise at $12.31 per share.
(Cost of $246,200)
11-Dec-07 20,000ISIS Automatic Sale at $17.37 per share.
(Proceeds of $347,400)
30-Nov-07 29,851ISIS Option Exercise at $5.15 - $5.15 per share.
(Cost of about $154,000)
30-Nov-07 29,851ISIS Automatic Sale at $18.03 per share.
(Proceeds of $538,213)
28-Nov-07 30,000ISIS Option Exercise at $5.15 - $5.15 per share.
(Cost of about $155,000)
28-Nov-07 30,000ISIS Automatic Sale at $18.01 - $18.01 per share.
(Proceeds of about $540,000)
    * Indicates that some (or all) shares are held indirectly (e.g. in a trust, by a spouse, etc.)

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