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Insider Filings - CROOKE STANLEY T
Last Updated 
29-Apr-13
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CROOKE STANLEY T: Declared Holdings
Company/RelationshipReportedShares  Ownership
Isis Pharmaceuticals, Inc.
Officer
NasdaqGS:ISIS
(historical quotes, profile, other insiders) 		22-Apr-13
24-Apr-13		1,661
   825,391
827,052		  Direct
  Indirect  
  Total

Insider & restricted shareholder transactions reported over the last two years
DateSharesStockTransaction
24-Apr-13 *10,000ISIS Automatic Sale at $22.12 per share.
(Proceeds of $221,200)
23-Apr-13 *30,000ISIS Sale at $22.10 per share.
(Proceeds of $663,000)
22-Apr-13 20,000ISIS Automatic Sale at $20.99 per share.
(Proceeds of $419,799)
22-Apr-13 *10,000ISIS Automatic Sale at $20.99 per share.
(Proceeds of $209,899)
22-Apr-13 20,000ISIS Option Exercise at $7.26 per share.
(Cost of $145,200)
19-Apr-13 30,000ISIS Option Exercise at $7.26 per share.
(Cost of $217,800)
19-Apr-13 30,000ISIS Automatic Sale at $20.01 per share.
(Proceeds of $600,300)
16-Jan-13 *143ISIS Sale at $14 per share.
(Proceeds of $2,002)
16-Jan-13 1,317ISIS Sale at $14 per share.
(Proceeds of $18,438)
15-Jan-13 2,978ISIS Option Exercise at $0 per share.
15-Jan-13 *317ISIS Option Exercise at $0 per share.
21-Sep-12 29,462ISIS Automatic Sale at $14.06 per share.
(Proceeds of $414,235)
21-Sep-12 29,462ISIS Option Exercise at $6.84 per share.
(Cost of $201,520)
20-Sep-12 30,000ISIS Option Exercise at $5.25 - $6.84 per share.
20-Sep-12 30,000ISIS Automatic Sale at $15.01 per share.
(Proceeds of $450,300)
19-Sep-12 30,000ISIS Automatic Sale at $14.82 per share.
(Proceeds of $444,600)
19-Sep-12 30,000ISIS Option Exercise at $5.25 per share.
(Cost of $157,500)
13-Sep-12 27,074ISIS Automatic Sale at $14.55 per share.
(Proceeds of $393,926)
13-Sep-12 27,074ISIS Option Exercise at $5.25 per share.
(Cost of $142,138)
6-Sep-12 *12,612ISIS Automatic Sale at $15 - $15.04 per share.
(Proceeds of about $189,000)
6-Sep-12 17,388ISIS Automatic Sale at $15 - $15.04 per share.
(Proceeds of about $261,000)
6-Sep-12 *12,612ISIS Option Exercise at $5.25 - $6.84 per share.
6-Sep-12 17,388ISIS Option Exercise at $5.25 per share.
(Cost of $91,287)
5-Sep-12 15,000ISIS Option Exercise at $5.25 per share.
(Cost of $78,750)
5-Sep-12 15,000ISIS Automatic Sale at $14.82 per share.
(Proceeds of $222,300)
4-Sep-12 30,000ISIS Option Exercise at $5.25 per share.
(Cost of $157,500)
4-Sep-12 30,000ISIS Automatic Sale at $14.11 per share.
(Proceeds of $423,300)
21-Dec-11 16,720ISIS Option Exercise at $5.80 per share.
(Cost of $96,976)
21-Dec-11 *1,080ISIS Option Exercise at $5.80 per share.
(Cost of $6,264)
21-Dec-11 16,720ISIS Automatic Sale at $6.92 per share.
(Proceeds of $115,702)
21-Dec-11 *1,080ISIS Automatic Sale at $6.92 per share.
(Proceeds of $7,473)
20-Dec-11 27,000ISIS Option Exercise at $5.80 per share.
(Cost of $156,600)
20-Dec-11 *1,700ISIS Option Exercise at $5.80 per share.
(Cost of $9,860)
20-Dec-11 27,000ISIS Automatic Sale at $6.82 - $6.92 per share.
(Proceeds of about $185,000)
20-Dec-11 *1,700ISIS Automatic Sale at $6.82 - $6.92 per share.
(Proceeds of about $12,000)
19-Dec-11 *1,100ISIS Option Exercise at $5.80 per share.
(Cost of $6,380)
19-Dec-11 17,000ISIS Option Exercise at $5.80 per share.
(Cost of $98,600)
19-Dec-11 17,000ISIS Automatic Sale at $6.82 - $6.9 per share.
(Proceeds of about $117,000)
19-Dec-11 *1,100ISIS Automatic Sale at $6.82 - $6.9 per share.
(Proceeds of about $7,546)
16-Dec-11 *1,500ISIS Automatic Sale at $6.79 per share.
(Proceeds of $10,185)
16-Dec-11 15,000ISIS Option Exercise at $5.80 per share.
(Cost of $87,000)
16-Dec-11 *1,500ISIS Option Exercise at $5.80 per share.
(Cost of $8,700)
16-Dec-11 15,000ISIS Automatic Sale at $6.79 per share.
(Proceeds of $101,850)
    * Indicates that some (or all) shares are held indirectly (e.g. in a trust, by a spouse, etc.)

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