Insider Trades - O'NEIL PATRICK R.

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O'NEIL PATRICK R.: Declared Holdings
Company/Relationship	Reported	Shares	Ownership
Isis Pharmaceuticals, Inc. Officer NasdaqGS:ISIS (historical quotes, profile, other insiders)	23-Apr-13	1,324	Direct

Insider & restricted shareholder transactions reported over the last two years
Date Shares Stock Transaction
23-Apr-13 27,320 ISIS Option Exercise at $8 - $15.38 per share.
23-Apr-13 27,320 ISIS Automatic Sale at $22.13 per share.
(Proceeds of $604,591)
19-Apr-13 15,000 ISIS Option Exercise at $14.18 - $15.38 per share.
(Cost of about $222,000)
19-Apr-13 15,000 ISIS Automatic Sale at $19.60 - $21.01 per share.
(Proceeds of about $305,000)
12-Apr-13 5,460 ISIS Automatic Sale at $19.60 - $19.62 per share.
(Proceeds of about $107,000)
12-Apr-13 5,460 ISIS Option Exercise at $14.18 - $14.47 per share.
(Cost of about $78,000)
21-Mar-13 9,000 ISIS Option Exercise at $14.18 per share.
(Cost of $127,620)
21-Mar-13 9,000 ISIS Automatic Sale at $19.26 per share.
(Proceeds of $173,340)
4-Mar-13 11,700 ISIS Automatic Sale at $15.82 per share.
(Proceeds of $185,094)
4-Mar-13 11,700 ISIS Option Exercise at $11.12 - $11.27 per share.
(Cost of about $131,000)
19-Feb-13 1,600 ISIS Automatic Sale at $14.80 per share.
(Proceeds of $23,680)
19-Feb-13 1,600 ISIS Option Exercise at $10.29 per share.
(Cost of $16,464)
15-Feb-13 350 ISIS Option Exercise at $10.29 per share.
(Cost of $3,601)
15-Feb-13 350 ISIS Automatic Sale at $14.80 - $14.82 per share.
(Proceeds of about $5,183)
13-Feb-13 6,239 ISIS Automatic Sale at $14.17 per share.
(Proceeds of $88,406)
13-Feb-13 6,100 ISIS Option Exercise at $7.25 - $8 per share.
(Cost of about $47,000)
30-Jan-13 2,000 ISIS Automatic Sale at $14.82 per share.
(Proceeds of $29,640)
30-Jan-13 2,000 ISIS Option Exercise at $10.29 per share.
(Cost of $20,580)
29-Jan-13 300 ISIS Automatic Sale at $13.40 per share.
(Proceeds of $4,020)
17-Jan-13 242 ISIS Sale at $14.16 per share.
(Proceeds of $3,426)
15-Jan-13 542 ISIS Option Exercise at $0 per share.
4-Jan-13 1,296 ISIS Automatic Sale at $10.76 per share.
(Proceeds of $13,944)
1-Jan-13 431 ISIS Acquisition (Non Open Market) at $8.87 per share.
(Value of $3,822)
1-Jan-13 2,328 ISIS Statement of Ownership

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Insider & restricted shareholder transactions reported over the last two years
Date	Shares	Stock	Transaction
23-Apr-13	27,320	ISIS	Option Exercise at $8 - $15.38 per share.
23-Apr-13	27,320	ISIS	Automatic Sale at $22.13 per share. (Proceeds of $604,591)
19-Apr-13	15,000	ISIS	Option Exercise at $14.18 - $15.38 per share. (Cost of about $222,000)
19-Apr-13	15,000	ISIS	Automatic Sale at $19.60 - $21.01 per share. (Proceeds of about $305,000)
12-Apr-13	5,460	ISIS	Automatic Sale at $19.60 - $19.62 per share. (Proceeds of about $107,000)
12-Apr-13	5,460	ISIS	Option Exercise at $14.18 - $14.47 per share. (Cost of about $78,000)
21-Mar-13	9,000	ISIS	Option Exercise at $14.18 per share. (Cost of $127,620)
21-Mar-13	9,000	ISIS	Automatic Sale at $19.26 per share. (Proceeds of $173,340)
4-Mar-13	11,700	ISIS	Automatic Sale at $15.82 per share. (Proceeds of $185,094)
4-Mar-13	11,700	ISIS	Option Exercise at $11.12 - $11.27 per share. (Cost of about $131,000)
19-Feb-13	1,600	ISIS	Automatic Sale at $14.80 per share. (Proceeds of $23,680)
19-Feb-13	1,600	ISIS	Option Exercise at $10.29 per share. (Cost of $16,464)
15-Feb-13	350	ISIS	Option Exercise at $10.29 per share. (Cost of $3,601)
15-Feb-13	350	ISIS	Automatic Sale at $14.80 - $14.82 per share. (Proceeds of about $5,183)
13-Feb-13	6,239	ISIS	Automatic Sale at $14.17 per share. (Proceeds of $88,406)
13-Feb-13	6,100	ISIS	Option Exercise at $7.25 - $8 per share. (Cost of about $47,000)
30-Jan-13	2,000	ISIS	Automatic Sale at $14.82 per share. (Proceeds of $29,640)
30-Jan-13	2,000	ISIS	Option Exercise at $10.29 per share. (Cost of $20,580)
29-Jan-13	300	ISIS	Automatic Sale at $13.40 per share. (Proceeds of $4,020)
17-Jan-13	242	ISIS	Sale at $14.16 per share. (Proceeds of $3,426)
15-Jan-13	542	ISIS	Option Exercise at $0 per share.
4-Jan-13	1,296	ISIS	Automatic Sale at $10.76 per share. (Proceeds of $13,944)
1-Jan-13	431	ISIS	Acquisition (Non Open Market) at $8.87 per share. (Value of $3,822)
1-Jan-13	2,328	ISIS	Statement of Ownership