SAN DIEGO, CA--(MARKET WIRE)--Oct 31, 2008 -- Cypress Bioscience, Inc. (NasdaqGM:CYPB - News) today announced that Michael R. Hufford, PhD, its Vice President of Corporate Development, will present at the Oppenheimer 19th Annual Healthcare Conference on November 4, 2008.

The Oppenheimer conference is being held at the Waldorf-Astoria Hotel in New York, NY. Dr. Hufford is scheduled to present on Tuesday, November 4th at 12:00 p.m. Eastern Time.

Investors, analysts and the general public are invited to listen to a live audio broadcast of this presentation over the Internet. The broadcast can be accessed at http://www.veracast.com/webcasts/opco/healthcare08/39207214.cfm.

About Cypress Bioscience, Inc.

Cypress Bioscience, Inc. is developing therapeutics and personalized medicine services, to facilitate improved and individualized patient care. Cypress' goal is to address the evolving needs of specialist physicians and their patients by identifying unmet medical needs in the areas of pain, rheumatology, and physical medicine and rehabilitation, including challenging disorders such as fibromyalgia and rheumatoid arthritis. We intend to use this approach to improve patient care and create a unique partnership with physicians.

For more information about Cypress, please visit the Company's website at www.cypressbio.com.

     For additional information please contact:
     For Cypress Bioscience:
     Michael Hufford
     VP Corporate Development
     Mary Gieson
     Investor Relations
     (858) 452-2323
     Email Contact