Item 1.01 Entry into a Material Definitive Agreement.

On March 8, 2013, Cornerstone Therapeutics Inc. (the "Company") executed an amendment (the "Amendment") to the Amended and Restated Development and Manufacturing Agreement between EKR Therapeutics, Inc., the Company's wholly owned subsidiary, and Baxter Healthcare Corporation ("Baxter") dated November 6, 2009 (the "Original Agreement"). The effective date of the Amendment is February 27, 2013. Pursuant to the terms of the Original Agreement, as amended (collectively, the "Agreement"), Baxter manufactures all the Company's CARDENE RTU bags.

The Amendment extends the term of the Agreement to December 31, 2019, unless earlier terminated. Pursuant to the Amendment, the Agreement is no longer subject to automatic renewal after the initial term. The Amendment also amends the annual purchase obligations, penalties, and supply price of CARDENE RTU bags, including by providing for the annual purchase obligations and supply prices during the remaining term of the Agreement.

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