Item 2.02 Results of Financial Operations and Financial Condition.

On February 27, 2013, ViroPharma Incorporated (the "Company") issued a press release announcing its financial results for its fourth quarter and twelve months ended December 31, 2012. In its press release, the Company included certain historical non-U.S. Generally Accepted Accounting Principles ("non-GAAP") financial measures as defined in Regulation G promulgated by the Securities and Exchange Commission for each of the three-month and twelve month periods ended December 31, 2012 and December 31, 2011 and as of December 31, 2012. Reconciliations for such historical non-GAAP financial measures are attached to or included in the press release furnished as Exhibit 99.1. The Company believes that its presentation of historical non-GAAP financial measures provides useful supplementary information to and facilitates additional analysis by investors. These historical non-GAAP financial measures are in addition to, not a substitute for, or superior to, measures of financial performance prepared in accordance with U.S. Generally Accepted Accounting Principles.

Item 9.01 Financial Statements and Exhibits.

The following exhibits are attached to this Form 8-K:

(d) Exhibit No. Description

99.1 Press release dated February 27, 2013 announcing financial results.

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