On February 27, 2013, management of Prosperity Bancshares, Inc. (the "Company") presented information to investors at the Keefe, Bruyette, & Woods 2013 Bank Conference in Boston regarding the Company's business and operational results for the fourth quarter and year ended December 31, 2012. The slide presentation given at this conference is furnished as Exhibit 99.1 to this Current Report on Form 8-K. The foregoing description is qualified by reference to such exhibit.

As provided in General Instruction B.2 to Form 8-K, the information in Item 7.01 and Exhibit 99.1 of this Current Report on Form 8-K is being furnished to the Securities and Exchange Commission and shall not be deemed "filed" for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), or otherwise subject to the liabilities of that section, and such information shall not be deemed incorporated by reference in any filing under the Securities Act of 1933, as amended, or the Exchange Act, except as shall be expressly set forth by specific reference in such filing.

(d) Exhibits. The following is furnished as an exhibit to this Current Report on Form 8-K:

             Exhibit
             Number    Description of Exhibit

             99.1      Investor presentation given February 27, 2013