Item 1.01. Entry into Material Definitive Agreement.

The information set forth in Item 3.03 of this Current Report with respect to the Amended Warrants (as defined below) is incorporated herein by reference.

Item 3.03. Material Modification to Rights of Security Holders.

On February 26, 2013, CombiMatrix Corporation (the "Company") entered into an Amendment No. 1 to Common Stock Purchase Warrants (the "Amendments") with each of the holders (the "Holders") of certain of the Company's warrants to purchase up to an aggregate of 939,260 shares of the Company's Common Stock, $0.001 par value per share, that were originally issued on October 1, 2012 and December 6, 2012 (the "Warrants").

The Warrants as originally issued were not exercisable for the first six months following the applicable issue date of each Warrant, which delayed their exercise until April 1, 2013, with respect to the Warrants issued on October 1, 2013, and June 6, 2013, with respect to the Warrants issued on December 6, 2012. On February 22, 2013, the Company's board of directors approved amending each of the Warrants to permit each Warrant to be immediately exercisable in full. Upon the Company entering into an Amendment with each Holder, each of the Warrants became exercisable in full as of February 22, 2013. By taking these actions, the Company accelerates the potential exercise of the Warrants by the Holders thereof and the receipt of proceeds from the exercise of such Warrants.

Item 9.01. Financial Statements and Exhibits.

(a) Not Applicable.

(b) Not Applicable.

(c) Not Applicable.

(d) Exhibits.

10.1 Form of Amendment No. 1 to Common Stock Purchase Warrant dated February 26, 2013

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