Item 4.01 Changes in Registrant's Certifying Accountant.

The Audit Committee of the Board of Directors (the "Audit Committee") of CryoLife, Inc. (the "Company") has completed a competitive process to review the appointment of the Company's independent registered public accounting firm for the fiscal year ending December 31, 2013 ("fiscal 2013").

As a result of this process on February 18, 2013, the Audit Committee appointed Ernst & Young LLP as its principal independent accountant to audit the Company's fiscal 2013 financial statements and dismissed Deloitte & Touche LLP ("Deloitte & Touche") as its principal independent accountant.

The reports on CryoLife's financial statements by Deloitte & Touche during the last two fiscal years and any subsequent interim period did not contain an adverse opinion or a disclaimer of opinion, and were not qualified or modified as to uncertainty, audit scope, or accounting principles. Also, there were no disagreements with Deloitte & Touche on any matter of accounting principles or practices, financial statement disclosure, or auditing scope or procedure during this time that, if not resolved to the satisfaction of Deloitte & Touche, would have caused Deloitte & Touche to make a reference to the subject matter of any such disagreement in connection with its report on CryoLife's financial statements.