On February 21, 2013, Onyx Pharmaceuticals, Inc. issued a press release announcing financial results for the full year and fourth quarter ended December 31, 2012. A copy of that press release is furnished as Exhibit 99.1 to this report.

This information in this Item 2.02, including Exhibit 99.1, shall not be deemed "filed" for purposes of Section 18 of the Securities Exchange Act of 1934, as amended, or otherwise subject to the liabilities of that Section or Sections 11 and 12(a)(2) of the Securities Act of 1933, as amended. The information contained in this Item 2.02 and in Exhibit 99.1 shall not be incorporated by reference into any filing with the U.S. Securities and Exchange Commission made by Onyx Pharmaceuticals, Inc., whether made before or after the date hereof, regardless of any general incorporation language in such filing.

(d) Exhibits

Exhibit Number                               Description

99.1             Press Release titled "Onyx Pharmaceuticals Reports Full Year and
                 Fourth Quarter 2012 Financial Results," dated February 21, 2013