Item 8.01 Other Events.

Cytokinetics announced today the opening to enrollment of a Phase II clinical trial of oral formulations of omecamtiv mecarbil. This trial, known as COSMIC-HF (Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure), is sponsored by Amgen in collaboration with Cytokinetics and is designed to evaluate the safety and efficacy of a novel cardiac muscle myosin activator, omecamtiv mecarbil, in patients with heart failure and left ventricular systolic dysfunction.

A copy of the press release is filed as Exhibit 99.1 to this Current Report on Form 8-K, and is incorporated herein by reference.

Item 9.01 Financial Statements and Exhibits.

(d) Exhibits.

The following Exhibit is filed as part of this Current Report on Form 8-K:

Exhibit No. Description

99.1 Press Release, dated February 12, 2013.

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