Second Amendment to Office Space Lease

On January 31, 2013, NuPathe Inc. (the "NuPathe") entered into a Second Amendment to its Office Space Lease with Washington Street Associates II, L.P. (the "Lease"), pursuant to which NuPathe leases office and storage space for its corporate headquarters. The Second Amendment extends the term of the Lease from March 31, 2013 to May 31, 2013 at the current monthly rent. All other provisions of the Lease are unchanged by the Second Amendment and remain in full force and effect.

The foregoing is a summary description of certain terms of the Second Amendment and, by its nature, is incomplete. A copy of the Second Amendment is filed as Exhibit 99.1 to this Form 8-K and is incorporated herein by reference. Copies of the Lease and the First Amendment were previously filed as Exhibit No. 10.10 to the Company's Form S-1 Registration Statement (File No. 333-166825) filed on June 15, 2010 and Exhibit 10.12 to the Company's Form 10-K filed on March 18, 2011, respectively, and are incorporated herein by reference. All readers are encouraged to read the entire text of the Second Amendment, the First Amendment and the Lease.

Conversion of Series A Preferred Stock

All shares of NuPathe Inc. ("NuPathe") Series A Preferred Stock have converted into shares of common stock. As of February 4, 2013, 29,068,850 shares of NuPathe common stock were issued and outstanding and no shares of preferred stock were issued and outstanding.

(d) Exhibits.

Exhibit No.                           Description of Exhibit

99.1          Second Amendment to Office Space Lease, dated January 31, 2013, by and
              between Washington Street Associates II, L.P. and NuPathe Inc.