Item 1.01 Entry into a Material Definitive Agreement.

On January 29, 2013, Spectrum Pharmaceuticals, Inc. (the "Company"), entered into a Second Amendment (the "Amendment") to the License, Development, Supply and Distribution Agreement, dated October 28, 2008, as amended June 13, 2011, by and among the Company, Allergan Sales, LLC, Allergan USA, Inc. and Allergan, Inc. (the Allergan entities collectively referred to as "Allergan") Under the Amendment, among other things, the parties agreed to restructure their collaboration with respect to Apaziquone, with Spectrum buying back the rights it originally licensed to Allergan in the U.S., Europe and other territories in exchange for a tiered single digit royalty not to exceed mid single digits on certain products containing Apaziquone, and Allergan being relieved of its obligations for development, commercialization and other activities.

The foregoing description of Amendment does not purport to be complete and is qualified in its entirety by Amendment, which will be filed as an Exhibit to the Company's Form 10-K for the annual period ended December 31, 2012. The Company intends to submit a FOIA confidential treatment request to the Securities and Exchange Commission pursuant to Rule 24b-2 under the Securities Exchange Act of 1934, as amended, requesting that it be permitted to redact certain portions of the Amendment. The omitted material will be included in the request for confidential treatment.

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