Item 1.01. Entry into a Material Definitive Agreement.

Extension of Terms of Supply and Distribution Agreement with Kawasumi Laboratories, Inc.

On January 30, 2013, Medisystems Corporation ("Medisystems"), a wholly-owned subsidiary of NxStage Medical, Inc. ("NxStage"), and Kawasumi Laboratories, Inc. ("Kawasumi") agreed to extend the terms of their Supply and Distribution Agreement dated as of February 1, 2001. The Agreement, which governs Medisystems' purchase of needle sets from Kawasumi, will now be extended to February 1, 2017, which term may be extended by the mutual agreement of the parties.

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