Summary of OPEXA THERAPEUTICS, INC.

Item 1.01. Entry into a Material Definitive Agreement

Pursuant to the financing effected by Opexa Therapeutics, Inc. (the "Company") in July 2012 (the "July 2012 Note Financing"), which entailed the Company's issuance of 12% Convertible Secured Promissory Notes (the "Notes"), cash in the amount of $1,000,000 (the "Cash Collateral") has been maintained in a segregated account and subject to a control agreement in favor of Alkek and Williams Ventures, Ltd., as collateral agent for all purchasers of the Notes. Pursuant to a Waiver and Omnibus Amendment executed by the holders of at least two-thirds (66-2/3%) of the principal amount of the outstanding Notes and accepted by the Company, the amount of the Cash Collateral has been reduced to $500,000. In exchange for such reduction, the Company has issued warrants (the "Warrants") to the holders of the Notes to purchase an aggregate of 187,500 shares of the Company's common stock (the "Common Stock"). The form of Warrant is attached hereto as Exhibit 4.1 and incorporated herein by reference.

The Warrants have an exercise price of $1.21 per share and a five-year term. The Company can redeem the Warrants at $0.01 per underlying share of Common Stock if the Common Stock closes at or above $10.00 per share for 20 consecutive trading days.

The Warrants contain a limitation on exercise, as applicable, such that the Warrant may not be exercised to the extent the holder thereof would beneficially own in excess of 19.9% of the Common Stock outstanding or control in excess of 19.9% of the total voting power of the Company's outstanding securities, unless and until the Company obtains shareholder approval permitting such issuance of shares.

Purchasers of Notes from the Company in the July 2012 Note Financing, and thus recipients of Warrants pursuant to the reduction in the Cash Collateral, include several existing large shareholders of the Company as well as three members of the Company's Board of Directors. Entities affiliated with director Scott B. Seaman will receive Warrants to acquire an aggregate of 59,670 shares of Common Stock, director David E. Jorden will receive a Warrant to acquire 5,278 shares of Common Stock, and director and President & Chief Executive Officer Neil K. Warma will receive a Warrant to acquire 688 shares of Common Stock.

Item 3.02 Unregistered Sales of Equity Securities

The disclosure in Item 1.01 above is incorporated herein by reference. The offers and issuance of the Warrants were made without registration under the Securities Act of 1933, as amended (the "Act"), or the securities laws of applicable states, in reliance on the exemptions provided by Section 4(2) of the Act and Regulation D under the Act and in reliance on similar exemptions under applicable state laws, based upon representations made by the recipients of the Warrants (each of whom is an "accredited investor" as such term is defined in Rule 501(a) of Regulation D).