Item 5.02 Departure of Directors or Certain Officers; Election of
Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.

(e) As previously reported, effective December 11, 2012, the employment of Gregory E. Papaz, our former Senior Vice President, U.S. Commercial Operations, was terminated. Effective January 22, 2013, Mr. Papaz entered into a separation agreement with us entitling him to receive severance benefits, which will include fifteen months of salary continuation and reimbursement for medical benefits, accelerated vesting and extended exercisability of outstanding equity awards and reimbursement for certain expenses. In exchange for the benefits provided in the separation agreement, Mr. Papaz has agreed to provide us with a general release of claims.

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