Base Salary Increases and Payment of Bonuses to Named Executive Officers

On January 16, 2013, the Board of the Company approved base salary increases for 2013 and cash bonus payments for the 2012 fiscal year to be paid to the Company's named executive officers. Under the Company's bonus program, the target performance bonus for John L. Higgins, the Company's President and Chief Executive Officer, is 75% of base salary, the target bonus for Matthew W. Foehr, the Company's Executive Vice President and Chief Operating Officer, is 50% of base salary and the target bonus for the other named executive officers is 40% of base salary. Bonus payments were based on the Board's evaluation of performance goals for 2012. Such goals related to the achievement of certain corporate organizational and infrastructure objectives and the advancement of the Company's clinical development programs.

The salary increases were previously reported incorrectly and certain figures below in the column marked "2013 Base Salary" have been revised to reflect the actual increases.

Name and Title                           2013 Base Salary          2012 Bonus
John L. Higgins,                             $500,780               $363,388
President and Chief Executive
Officer
Matthew W. Foehr, Executive Vice             $368,431               $179,813
President and Chief Operating
Officer
John P. Sharp,                               $301,490               $102,382
Vice President, Finance and Chief
Financial Officer
Charles S. Berkman, Vice President,          $283,605               $110,081
Secretary and General Counsel
Nishan de Silva, M.D., M.B.A.,               $295,000                $98,508
Vice President of Corporate
Development