Item 1.01 Entry into a Material Definitive Agreement.

On January 11, 2013, we entered into an Assignment and Assumption of Lease and Novation (the "Assumption Agreement") with eBioscience, Inc. ("eBioscience"), pursuant to which we acquired all of eBioscience's rights and obligations under that certain Office Lease dated April 27, 2009 between BMR-10240 Science Center Drive LLC (the "Landlord"), as landlord and successor-in-interest to TC Torrey Pines, LLC, and eBioscience (the "Lease"), including the right to occupy approximately 49,347 square feet of commercial office and laboratory space located in San Diego, California.

The initial term of the Lease will expire in July 2015. Pursuant to the terms of the Lease, our basic rent will be $123,861 per month through June 30, 2013, $127,315 per month thereafter through June 30, 2014 and $129,783 per month for the remainder of the Lease. In addition, we have the option to extend the Lease for an additional five-year term, which would commence upon the expiration of the initial term. In the event we choose to extend the term of the Lease, the minimum monthly rent payable for such additional term will be 95% of the then-prevailing market rate.

Under the terms of the Lease, we are required to maintain certain levels of insurance and are required to indemnify the Landlord for losses incurred that are related to our use or occupancy of the property.

Pursuant to the Assumption Agreement, we also acquired rights to the prepaid rents and security deposit held by the Landlord, which such amounts will be reimbursed by us.

The foregoing summaries of the Assumption Agreement and the Lease does not purport to be complete and are qualified in their entirety by reference to the Assumption Agreement and the Lease, each of which will be attached as an exhibit to our Annual Report on Form 10-K for the year ending December 31, 2012.

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