Jeffrey Riley, Chief Executive Officer and President of Synthetic Biologics, Inc. (the "Company"), will be making a presentation on January 9, 2013 at the Sixth Annual OneMedForum San Francisco 2013, as well as making several investor presentations during the next few weeks. In connection with the presentations, Mr. Riley intends to discuss the slide presentation furnished as Exhibit 99.1 hereto, which is incorporated herein by reference.

The slide presentation attached as Exhibit 99.1 to this Report includes "safe harbor" language pursuant to the Private Securities Litigation Reform Act of 1995, as amended, indicating that certain statements contained in the slide presentation or in the press release are "forward-looking" rather than historical.

The information included in this Item 7.01 and in Exhibit 99.1 shall not be deemed filed for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), or otherwise subject to the liabilities of that
Section or incorporated by reference in any filing under the Securities Act of 1933, as amended, or the Exchange Act, except as shall be expressly set forth by specific reference in such a filing. The Company undertakes no duty or obligation to update or revise information included in this Report or any of the Exhibits.

(d) Exhibits

The following exhibit is being filed as part of this Report.

   Exhibit
   Number                                Description

    99.1      Presentation materials to be provided at Synthetic Biologics,
              Inc.'s investor presentations