ITEM 1.01 Entry into a Material Definitive Agreement.

On December 14, 2012, Synta Pharmaceuticals Corp. (the "Company") and its wholly owned subsidiary, Synta Securities Corp., as guarantor, entered into a Seventh Amendment, effective October 1, 2012 (the "Amendment"), to the Company's $15 million Loan and Security Agreement with General Electric Capital Corporation ("GECC"), in its capacity as agent for GECC and MidCap Funding III, LLC as lenders, dated September 30, 2010, as amended on November 9, 2010, March 3, 2011, July 1, 2011, January 23, 2012, and December 6, 2012 (the "GECC Term Loan"). The GECC Term Loan is secured by substantially all of the Company's assets, except its intellectual property. The GECC Term Loan also provides for a springing security interest in favor of GECC, as agent for the lenders, in the Company's intellectual property, which would be triggered in the event that the Company is not in compliance with certain cash usage covenants, as defined in the GECC Term Loan. The Amendment provides that the springing security interest in the Company's intellectual property may not be triggered until after December 20, 2012.

ITEM 9.01 Financial Statements and Exhibits.

(d) Exhibits. Exhibit Number Description 10.1 Seventh Amendment, dated as of December 14, 2012, to Loan and Security Agreement, dated as of September 30, 2010, as amended, by and among Synta Pharmaceuticals Corp., Synta Securities Corp., General Electric Capital Corporation, and MidCap Funding III, LLC.

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