Item 1.01. Entry into a Material Definitive Agreement

On December 17, 2012, Dynavax Technologies Corporation (the "Company") entered into a Lease Agreement (the "New Lease") with 2929 Seventh Street, L.L.C (the "Landlord") for new office space located at 2919 Seventh Street, Berkeley, California. The New Lease covers the rental of approximately 14,461 square feet of additional space for a term of five (5) years commencing on the date the Landlord work is substantially complete, which is expected to be June 1, 2013.

Also on December 17, 2012, the Company entered into a fourth amendment to the Original Lease (as defined below) (the "Fourth Amendment") with respect to the Company's current office and laboratory space located at 2929 Seventh Street, Berkeley, California (the "Berkeley Space"). The initial lease for the Berkeley Space became effective on January 7, 2004 (the "Original Lease") and was subsequently amended by the First Amendment to Lease, dated May 21, 2004, the Second Amendment to the Lease, dated October 12, 2010, and the Third Amendment to Lease, dated April 1, 2011.The Fourth Amendment extends the term of the Original Lease, as amended, by eight (8) months and shall expire upon the expiration of the New Lease, but no later than June 30, 2018.

The foregoing description of the terms of the New Lease and the Fourth Amendment does not purport to be complete and is qualified in its entirety by reference to the New Lease and the Fourth Amendment.

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