On November 30, 2012, KYTHERA Biopharmaceuticals, Inc. (the "Company") entered into Amendment No. 3 (the "Amendment") to its Loan and Security Agreement No. 1991 dated as of March 21, 2011, as amended, with Lighthouse Capital Partners VI, L.P. ("Lighthouse") to extend the term of the credit facility until February 28, 2013. In addition, pursuant to the terms of the Amendment, Lighthouse is not obligated to advance any additional funds to the Company until January 2, 2013 and, subsequently, the Company may draw up to a maximum of $5.0 million during each of the calendar months of January 2013 and February 2013, for an aggregate maximum of $10.0 million. Following termination of the credit facility, Lighthouse will not be obligated to advance any funds to the Company under the Loan and Security Agreement.

The foregoing description of the material terms of the Amendment is qualified in its entirety by reference to the full text of the Amendment, a copy of which is filed herewith as Exhibit 10.1 to this Current Report on Form 8-K and is incorporated herein by reference.

The following Exhibit is filed as part of this Current Report on Form 8-K.

(d) Exhibits

Exhibit Number                               Description

10.1             Amendment No. 3, dated November 30, 2012, to that certain Loan and
                 Security Agreement No. 1991, dated as of March 21, 2011, as amended,
                 by and between Lighthouse Capital Partners VI, L.P. and KYTHERA
                 Biopharmaceuticals, Inc.