ITEM 1.01 Entry Into a Material Definitive Agreement

On November 26, 2012, BioLife Solutions, Inc. (the "Company") entered into a Fourth Amendment to Lease (the "Fourth Lease Amendment") with Monte Villa Farms LLC (the "Landlord") to enlarge the premises leased by the Company, extend the term of the lease, dated as of August 1, 2007 (the "Original Lease"), and to make other modifications to the terms and conditions of the Original Lease, as amended by the First Amendment to Lease (the "First Lease Amendment"), entered into by the Company and Landlord on and dated as of November 4, 2008, the Second Amendment to Lease (the "Second Lease Amendment"), entered into by the Company on March 3, 2012 and the Third Amendment to the Lease (the Third Lease Amendment") entered into by the Company on June 15, 2012.

The premises leased pursuant to the Original Lease consisted of approximately 4,366 rentable square feet of space in the building (the "Building") located at 3303 Monte Villa Parkway, Bothell, Washington. The Company leased an additional 5,798 rentable square feet of space in the Building pursuant to the First Lease Amendment. The Second Lease Amendment expanded the premises leased by the Company from the Landlord to approximately 20,462 rentable square feet. The Third Lease Amendment expanded the premises to 20,761 rentable square feet. The Fourth Lease Amendment expanded the premises to 25,864 rentable square feet.

The foregoing summary is qualified in its entirety by reference to the text of the Fourth Lease Amendment, a copy of which will be attached as an exhibit to the Company's Annual Report on Form 10-K for the period ended December 31, 2012.

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