Item 1.01 Entry into a Material Definitive Agreement

Pressure BioSciences, Inc. ("PBI") and Cole-Parmer have signed a Supplier Agreement, under which Cole-Parmer will distribute the PBI Shredder SG3 System and processing tubes on a non-exclusive basis. Cole-Parmer sent out a press release announcing the introduction of the PBI Shredder SG3 System for sample preparation and analytical testing. A copy of the press release is attached hereto as Exhibit 99.1 and is incorporated herein in its entirety by reference.

Item 9.01 Financial Statements and Exhibits

(d) Exhibits

99.1 Cole-Parmer Press Release dated October 29, 2012

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