On November 7, 2012, OraSure Technologies, Inc. (the "Company") issued a press release announcing its consolidated financial results for the quarter ended September 30, 2012, and providing financial guidance for the fourth quarter of 2012. A copy of the press release is attached as Exhibit 99.1 to this Form 8-K and is incorporated herein by reference.

The information in this Item and attached Exhibit shall not be deemed "filed" for purposes of Section 18 of the Securities Exchange Act of 1934 or otherwise subject to the liabilities of that section, nor shall such information and Exhibit be deemed incorporated by reference in any filing under the Securities Act of 1933, except as shall be expressly set forth by specific reference in such a filing. The fact that the information and Exhibit are being furnished should not be deemed an admission as to the materiality of any information contained therein. The Company undertakes no duty or obligation to publicly update or revise the information contained in this Current Report or attached Exhibit.

On November 7, 2012, the Company held a webcast conference call with analysts and investors, during which Douglas A. Michels, the Company's President and Chief Executive Officer, and Ronald H. Spair, the Company's Chief Financial Officer and Chief Operating Officer, discussed the Company's consolidated financial results for the quarter ended September 30, 2012, provided financial guidance for the fourth quarter of 2012 and described certain business developments. A copy of the prepared remarks of Messrs. Michels and Spair is attached as Exhibit 99.2 to this Form 8-K and is incorporated herein by reference.

The information in this Item and attached Exhibit shall not be deemed "filed" for purposes of Section 18 of the Securities Exchange Act of 1934 or otherwise subject to the liabilities of that section, nor shall such information and Exhibit be deemed incorporated by reference in any filing under the Securities Act of 1933, except as shall be expressly set forth by specific reference in such a filing. The fact that the information and Exhibit are being furnished should not be deemed an admission as to the materiality of any information contained therein. The Company undertakes no duty or obligation to publicly update or revise the information contained in this Current Report or attached Exhibit.

(d) Exhibits

Exhibit
Number                                    Description

99.1         Press Release, dated November 7, 2012, announcing consolidated
             financial results of OraSure Technologies, Inc. for the quarter ended
             September 30, 2012, and providing financial guidance for the fourth
             quarter of 2012.

99.2         Prepared Remarks of Douglas A. Michels and Ronald H. Spair for OraSure
             Technologies, Inc. Third Quarter 2012 Analyst/Investor Conference Call
             Held November 7, 2012.


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Signatures

Pursuant to the requirements of the Securities and Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned, hereunto duly authorized.

Date: November 7, 2012 By: /s/ Jack E. Jerrett Jack E. Jerrett Senior Vice President, General Counsel and Secretary