Item 2.02. Results of Operations and Financial Condition.

On November 6, 2012, we issued a press release announcing our results for the quarter ended September 30, 2012 and will conduct a previously-announced, publicly-available conference call to discuss those results. A copy of this press release is attached as Exhibit 99.1 to this Current Report on Form 8-K and is incorporated herein by reference.

This information and Exhibit 99.1 hereto shall not be deemed "filed" for purposes of Section 18 of the Securities Exchange Act of 1934 (the "Exchange Act") or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference in any filing under the Securities Act of 1933 or the Exchange Act, except as expressly set forth by specific reference in such a filing.

Item 5.02. Departure of Directors or Certain Officers; Election of Directors;
Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.

(b) On November 2, 2012 Steven H. Holtzman, the Chair of our Board of Directors (the "Board") notified the Board of his decision to resign from our Board effective immediately. Mr. Holtzman indicated that he decided to resign to avoid the potential for a conflict of interest between his role as a member of Infinity's board of directors and his role as executive vice president, corporate development of Biogen Idec Inc. that could have arisen from both companies having product development programs focused on inflammatory disorders.

Item 7.01. Regulation FD Disclosure.

From time to time, we intend to conduct meetings with third parties in which our current corporate slide presentation is presented. A copy of this slide presentation, dated November 6, 2012, is attached as Exhibit 99.2 to this Current Report on Form 8-K and is incorporated herein by reference.

This information and Exhibit and 99.2 hereto shall not be deemed "filed" for purposes of Section 18 of the Securities Exchange Act of 1934 (the "Exchange Act") or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference in any filing under the Securities Act of 1933 or the Exchange Act, except as expressly set forth by specific reference in such a filing.

Item 8.01. Other Events.

The information in Item 5.02 is incorporated by reference into this Item 8.01. On November 5, 2012, following the resignation of Mr. Holtzman as the Chair of our Board, the Board elected Adelene Q. Perkins, President and CEO of the Company, to Chair of the Board.

Item 9.01. Financial Statements and Exhibits.

(d) The following exhibits are included in this report:

Exhibit
No. Description

99.1 Press release dated November 6, 2012

99.2 Presentation dated November 6, 2012

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