Item 1.01. Entry into a Material Definitive Agreement.

CombiMatrix Molecular Diagnostics, Inc. ("CMDX"), a wholly owned subsidiary of CombiMatrix Corporation, entered into an Amendment No. 4 to the Lease (the "Amendment") with PPC Goddard Investment, LLC, effective October 21, 2012, which further amended that certain Standard Industrial/Commercial Multi-Tenant Lease-Net, dated June 26, 2006, by and between CMDX and PPC Goddard Investment, LLC (as successor in interest of GFE Goddard Investment, LLC and Edison Spectrum Partners, LLC), as amended (the "Lease"). The Lease, as amended by the Amendment, governs CMDX's occupancy of its administrative offices and laboratory facilities located in Irvine, California. The Amendment, in part, (i) extends the term of the Lease by one year, and (ii) provides for monthly base rent of $1.15 per square foot for such additional year, or an aggregate monthly base rent of approximately $14,000.

The information set forth above is qualified in its entirety by reference to the actual terms of the Amendment attached hereto as Exhibit 10.1 and which is incorporated herein by reference.

Item 9.01. Financial Statements and Exhibits.

(a) Not Applicable.

(b) Not Applicable.

(c) Not Applicable.

(d) Exhibits.

10.1 Amendment No. 4 to the Lease effective as of October 21, 2012

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