Item 5.02 Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.

On October 23, 2012, the Board of Directors of Epocrates, Inc. (the "Company") appointed Andrew Hurd, the Company's President and Chief Executive Officer, as interim Chief Financial Officer, effective immediately. Mr. Hurd has served as the Company's President and Chief Executive Officer since March 2012 and will continue in this role.

Prior to joining the Company, Mr. Hurd served as Chairman and CEO of Carefx, a healthcare technology company acquired by Harris Corporation in 2011, from July 2005 to December 2011. There are no family relationships between Mr. Hurd and any director or executive officer of the Company, and he has no direct or indirect material interest in any transaction required to be disclosed pursuant to Item 404(a) of Regulation S-K.

No new compensatory or severance arrangements were entered into in connection with Mr. Hurd's appointment as interim Chief Financial Officer.

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