Item 1.01 Entry into a Material Definitive Agreement.

On September 27, 2012, Northwest Biotherapeutics, Inc. (the "Company") entered into a Note Purchase Agreement (the "Purchase Agreement") with a non-affiliated investor for the sale and issuance of a convertible promissory note in the principal amount of $500,000 (the "Note"), on the same terms and conditions upon which the Company previously entered into a financing of $1 million with the same investor on August 17, 2012.

The Note is convertible into common stock of the Company at a price of fifteen dollars ($15.00) per share, at the election of the Holder beginning 180 days after the issuance of the Note.

The Note matures 19 months after the issue date. Commencing 7 months after the issuance of the Note, the Company is required to begin amortizing the Note, with monthly payments over the remaining 12 months of the term. It is the Company's choice each month whether to make that month's payment in cash or in common stock of the Company, as long as the Company does not default. If the Company elects to make any such monthly payment in stock, the conversion price for such payment will be at a 20% discount to the market price at the time of the conversion for that payment.

The Note includes an original issue discount of ten percent, and transaction fees of $5,000. Interest on the Note accrues at a rate of 8% per annum. The Note contains customary default provisions, including provisions for potential acceleration of the Note, a default premium of 10%, default interest and potential requirements to deliver additional shares.

Item 2.03 Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant.

The information required to be disclosed in this Item 2.03 is incorporated herein by reference from Item 1.01.

Item 3.02 Unregistered Sales of Equity Securities.

The securities described in Item 1.01 above were offered and sold in reliance upon exemptions from registration pursuant to Section 4(2) under the Securities Act of 1933, as amended ("Securities Act"), and Rule 506 of Regulation D promulgated thereunder. The offering was made to an "accredited investor" (as defined by Rule 501 under the Securities Act). In addition, the issuance did not involve any public offering; the Registrant made no solicitation in connection with the sale other than communications with the investor; the Registrant obtained representations from the investor regarding its investment intent, experience and sophistication; and the investor either received or had access to adequate information about the Registrant in order to make an informed investment decision.