On September 12, 2012, the board of directors (the "Board") of Pacific Biosciences of California, Inc. (the "Company") appointed Lucy Shapiro, Ph.D., 72, as a Class I director to serve on the Board effective immediately.

Dr. Shapiro currently serves as the Virginia and D.K. Ludwig Professor of Cancer Research and the Director of the Beckman Center for Molecular and Genetic Medicine at Stanford University's School of Medicine, where she has been as a faculty member since 1989. Dr. Shapiro is a co-founder and has served as a director of Anacor Pharmaceuticals, Inc since its founding in 2000 and served as a non-executive director of Gen-Probe, Inc. from 2008 to 2012. In 1989, Dr. Shapiro founded Stanford University's Department of Developmental Biology, and served as its Chairman from 1989 to 1997. She previously served as Chair of the Department of Microbiology and Immunology in the College of Physicians and Surgeons of Columbia University. Dr. Shapiro holds a B.A. from Brooklyn College and a Ph.D. in Molecular Biology from the Albert Einstein College of Medicine.

As previously disclosed in the Company's proxy statement for the 2012 Annual Meeting of Stockholders, as a non-employee director, Dr. Shapiro will receive an annual retainer of $35,000. Pursuant to the Company's outside director equity compensation policy, Dr. Shapiro was automatically granted a stock option to purchase 35,000 shares of the Company's common stock on the date of her appointment to the Board.

On September 12, 2012, the Company issued a press release announcing the appointment of Dr. Shapiro to the Board. A copy of the press release is included as Exhibit 99.1. This information is intended to be furnished under Item 7.01 of Form 8-K and shall not be deemed "filed" for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), or incorporated by reference in any filing under the Securities Act of 1933, as amended, or the Exchange Act, except as shall be expressly set forth by specific reference in such a filing.

(d) Exhibits

Exhibit
  No.                                     Description

99.1         Press release dated September 12, 2012 titled "Pacific Biosciences
             Appoints Lucy Shapiro, Ph.D. to Board of Directors" (furnished and not
             filed herewith solely pursuant to Item 7.01).