On September 10, 2012, Sequenom, Inc. (the "Company") issued a press release titled "Sequenom Announces Proposed Offering of $100 Million of Convertible Senior Notes" (the "Launch Press Release") announcing the launch of its private offering to qualified institutional buyers in reliance on Rule 144A under the Securities Act of 1933, as amended. A copy of the Launch Press Release is attached hereto as Exhibit 99.1 and incorporated by reference herein.

In addition, in connection with the private offering described above, the Company is filing the information set forth in Exhibit 99.2 hereto with the Securities and Exchange Commission for the purpose of updating certain aspects of its publicly disclosed description of its risk factors, including relating to certain intellectual property and regulatory issues.

(d) Exhibits.

Exhibit
Number                                    Description

99.1         Press Release, dated September 10, 2012, titled "Sequenom Announces
             Proposed Offering of $100 Million of Convertible Senior Notes."

99.2         Updated risk factor disclosure.