Item 5.02. Departure of Directors or Certain Officers; Election of Directors;
Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.

The Board of Directors of Shire plc ("Shire") announced on September 4, 2012 that Dr. Steven Gillis will join the Board of Directors with effect from October 1, 2012. On joining the Board, Dr. Gillis will become a member of Shire's Science & Technology Committee and Remuneration Committee. Shire has issued the press release attached as Exhibit 99.01 which is incorporated by reference herein.

Item 9.01. Financial Statements and Exhibits

(d) Exhibits. The following exhibit is filed herewith:

99.01 Press Release dated September 4, 2012

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