Item 1.01. Entry into a Material Definitive Agreement.

On August 16, 2012, as contemplated by the prospectus related to the initial public offering of Durata Therapeutics, Inc. (the "Company"), the Company entered into a lease with T.K.J. Associates, LLC, as landlord, for approximately 17,800 square feet of office space at 322 East Main Street in Branford, Connecticut. The Company intends to use the leased premises for research and development, clinical and regulatory functions. As previously reported, the Company is in the process of relocating its corporate and commercial functions to its new Chicago, Illinois location. The lease term commences on the day after the substantial completion of tenant improvement construction being performed by the landlord, and expires on the last day of the month that is five years and two months thereafter. The Company has the option to extend the term of the lease for two additional five year periods upon at least ten months prior written notice. There are no scheduled rent payments due for the first two months of the lease term. Thereafter, the Company has agreed to pay aggregate rental fees of approximately $1.8 million over the remaining 60 month term. The lease also provides the Company with temporary office space at the same address until construction work on the leased premises is completed. The Company will provide a security deposit in the form of a letter of credit for the benefit of the landlord in the amount of $350,000, which amount will be reduced incrementally over the term of the lease.

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