On August 14, 2012, Rockwell Medical, Inc. (the "Company") entered into a Lease Renewal Agreement (the "Lease Renewal") with International Wixom, LLC (the "Landlord"), which renews the Lease Agreement dated October 23, 2000 (the "Lease") for the Company's Wixom, Michigan facility.

The Lease Renewal extends the term of the Lease through August 31, 2014, and lowers the monthly rent to $13,562. Terms of the Lease are otherwise unchanged.

The foregoing does not purport to be a complete description of the Lease Renewal and is qualified in its entirety by reference to the full text of the Lease Renewal, a copy of which is attached hereto as Exhibit 10.48 and is incorporated herein by reference.

The following exhibit is filed herewith:

Exhibit
number                               Exhibit Description

10.48       Lease Renewal Agreement dated August 14, 2012, by and between Rockwell
            Medical, Inc. and International-Wixom, LLC