Item 1.01. Entry into a Material Definitive Agreement.

On August 3, 2012, as contemplated by the prospectus related to the initial public offering of Durata Therapeutics, Inc. (the "Company"), the Company entered into a lease with 200 S. Wacker Property Owner, L.L.C., as landlord, for approximately 10,300 square feet of office space at 200 South Wacker Drive in Chicago, IL. The Company intends to use the leased premises for corporate and commercial functions. The lease term commences on the later to occur of the delivery of the premises to the Company with substantial completion of the tenant improvement construction being performed by the landlord and November 1, 2012, and expires five years and five months thereafter. The Company has the option to extend the term of the lease for one additional five year period. There are no scheduled rent payments due for the first 5 months of the lease term. Thereafter, the Company has agreed to pay aggregate rental fees of approximately $1.2 million over the remaining 60 month term. The lease also provides the Company with temporary office space at the same address until construction work on the leased premises is completed. The Company will provide a security deposit in the form of a letter of credit for the benefit of the landlord in the amount of $500,000, which amount will be reduced incrementally over the term of the lease.

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