Item 1.01. Entry into a Material Definitive Agreement.

On July 26, 2012, Dyax Corp. ("Dyax") and MedImmune Limited, formerly Cambridge Antibody Technology Limited ("MedImmune"), entered into an Amended and Restated License Agreement (the "Agreement"),which amended and restated the Amended and Restated License Agreement between Dyax and MedImmune dated as of July 30, 2007.

Under the Agreement, the term of the license granted by Dyax to MedImmune to use Dyax's antibody libraries to discover and develop antibody products has been extended for an additional five years to 2017. In consideration for this extension, certain terms associated with the license granted by MedImmune to Dyax under MedImmune's antibody phage display patents were also amended. The amended terms provide Dyax with an improved financial structure, including a reduced royalty obligation, and fewer contractual restrictions as it pertains to future activities under Dyax's Licensing and Funded Research Program, or LFRP. MedImmune will continue to receive milestone payments and low single-digit royalty payments in connection with antibody products developed and commercialized by Dyax or its licensees under the Agreement. For products developed by MedImmune or its licensees using Dyax's antibody libraries, no milestone payments are due but Dyax will receive low single-digit royalty payments.

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