On August 1, 2012, Alexza Pharmaceuticals, Inc. announced management promotions of James V. Cassella, Ph.D. as Executive Vice President, Research and Development, and Chief Scientific Officer, Darl Moreland as Senior Vice President, Quality, Mark K. Oki as Senior Vice President, Finance and Chief Financial Officer, and Ed Kamemoto, Ph.D. as Vice President, Regulatory Affairs. The press release is furnished as Exhibit 99.1 hereto, the contents of which are incorporated herein by reference.

(d) Exhibits.

Exhibit Number         Description

99.1                   Press Release titled "Alexza Announces Management
                       Promotions," dated August 1, 2012.