On June 27, 2012, RXi Pharmaceuticals Corporation (the "Company") entered into a lease (the "Office Lease") with Westborough Associates Building Five Limited Partnership to lease office space in the building known as Building Five in Westborough Office Park located at 1500 West Park Drive, Westborough, Massachusetts, covering approximately 2,150 square feet. The premises will be used by the Company for office space, replacing its previous office space in Worcester.

The Company moved into the new office space on or about June 29, 2012. The term of the lease commenced upon signing and will continue through April 30, 2014. The base rent for the premises is $37,625 per annum, payable monthly. The company is not required to pay any taxes or operating expenses under the Office Lease.

As provided in the Office Lease, the Company may renew the Office Lease for one two-year term by giving six months prior written notice to the landlord. The rental rate for this renewal period shall be 95% of fair market rental rate.

On June 28, 2012, the Company entered into a sublease (the "Laboratory Sublease") with Massachusetts Biomedical Initiatives, Inc., a Massachusetts Not For Profit Organization, to lease certain laboratory and office space at Gateway Park, 60 Prescott Street, Worcester, MA 01605. The premises will be used by the Company for laboratory space and supporting functions, replacing its existing laboratory space in Worcester.

The Company expects to move into the new premises on or about October 1, 2012. The term of the lease commences on October 1, 2012 and will continue for one year. The base rent for the premises is $25,200 per annum, payable monthly. The company is not required to pay any taxes or operating expenses under the Laboratory Sublease.

As provided in the Laboratory Sublease, the Company may extend the Laboratory Sublease on a month to month basis and shall have a sixty day termination notice requirement. The base rent during each year of any option term shall increase by 3.5% over the base rent for the prior year.

The information set forth above in Item 1.01 of this Current Report on Form 8-K regarding the Office Lease and Laboratory Sublease is incorporated into this Item 2.03 by reference.

(d) Exhibits

10.1    Lease Agreement dated June 27, 2012 between RXi Pharmaceuticals
        Corporation and Westborough Associates Building Five Limited Partnership

10.2    Sublease Agreement dated June 28, 2012 between RXi Pharmaceuticals
        Corporation and Massachusetts Biomedical Initiatives, Inc.

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