The Annual Meeting of Stockholders (the "Annual Meeting") of the Company was held on June 7, 2012. At the Annual Meeting, the stockholders voted on the following five proposals and cast their votes as described below.

Proposal 1. The individuals listed below were elected at the Annual Meeting to serve a one-year term on the Company's Board of Directors until the annual meeting of stockholders in 2013 and until their respective successors are duly elected and qualified or until their earlier resignation or removal.

                                                     BROKER
                               FOR       WITHHELD   NON-VOTES

Vipin K. Garg, Ph.D.        14,807,118    2,761     2,110,894

John H. Johnson             14,802,118    7,761     2,110,894

George B. Abercrombie       14,807,118    2,761     2,110,894

Jean-Paul Castaigne, M.D.   14,807,778    2,101     2,110,894

Aaron Davidson              14,805,578    4,301     2,110,894

Anne M. VanLent             14,807,778    2,101     2,110,894

Alex Zisson                 14,804,918    4,961     2,110,894

Proposal 2. The Company's stockholders approved the non-binding, advisory resolution on the executive compensation of the Company's named executive officers.

                                  BROKER
   FOR       ABSTAIN   AGAINST   NON-VOTES

14,393,501   404,301   12,077    2,110,894

Proposal 3. The option to hold advisory votes on the executive compensation of the Company's named executive officers on an annual basis received the highest number of votes from the Company's stockholders.

                                            BROKER
  1 YEAR     2 YEARS   3 YEARS   ABSTAIN   NON-VOTES

14,777,259    4,792    22,976     4,852    2,110,894

Proposal 4. The Company's stockholders approved the amendment and restatement of the Tranzyme, Inc. 2011 Stock Option and Incentive Plan.

                                 BROKER NON-
   FOR       ABSTAIN   AGAINST      VOTES

14,388,011    7,362    414,506    2,110,894

Proposal 5. The Company's stockholders ratified the selection of Ernst & Young LLP as the Company's independent registered public accounting firm for 2012.