Item 7.01 Regulation FD Disclosure.

On May 31, 2012, RXi Pharmaceuticals Corporation (the "Company") issued the press release attached as Exhibit 99.1 to this Current Report on 8-K, which press release is incorporated herein by reference.

The information in this Item 7.01 and Exhibit 99.1 is being "furnished" pursuant to Item 7.01 and shall not be deemed "filed" for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), or incorporated by reference into those filings of the Company that provide for the incorporation of all reports and documents filed by the Company under the Exchange Act.

Item 9.01 Financial Statements and Exhibits.

(d) Exhibits

99.1 Press release of RXi Pharmaceuticals Corporation dated May 31, 2012.

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