On May 25, 2012, we held our Annual Meeting of Stockholders at which the shareholders voted upon (i) the election of the Board's nominees, Dr. Jean-François Formela and Dr. Burton E. Sobel, to our Board of Directors for three-year terms ending at the 2015 Annual Meeting of Stockholders and (ii) the ratification of the selection of KPMG LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2012.

The stockholders elected both director nominees and ratified the selection of KPMG LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2012. The tabulation of votes cast with respect to each matter voted upon, as applicable, was as follows:

1. Election of Directors

      Nominee                           For         Withheld       Broker Non-Votes
      Jean-François Formela, M.D.     2,731,487       233,710              5,194,686
      Burton E. Sobel, M.D.           2,727,454       237,743              5,194,686

2. Ratification of the selection of KPMG LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2012

For Against Abstentions Broker Non-Votes 7,903,671 195,312 60,900 -