Item 5.07. Submission of Matters to a Vote of Security Holders.
At the Annual Meeting of Stockholders of The Medicines Company (the "Company"), held on May 22, 2012 (the "Annual Meeting"), stockholders considered and voted on the following proposals: (1) the election of four class 3 directors for terms expiring at the 2015 annual meeting of stockholders; (2) the approval, on an advisory basis, of the compensation of the Company's named executive officers as presented in the Company's proxy statement delivered to stockholders in connection with the Annual Meeting; and (3) the ratification of the appointment of Ernst & Young LLP as the Company's independent registered accounting firm for the current fiscal year.

The voting results at the Annual Meeting with respect to each of the matters described above, were as follows:

1. The four directors were elected based upon the following votes:

For Withheld Broker Non-Votes Armin M. Kessler 43,189,150 1,140,776 2,871,823 Robert G. Savage 43,257,588 1,072,338 2,871,823

Glenn P. Sblendorio 40,059,528 4,270,398 2,871,823 Melvin K. Spigelman 44,212,748 117,178 2,871,823

2. The Company's executive compensation was approved, on an advisory basis, based upon the following votes:

For Against Abstain Broker Non-Votes 43,203,461 1,114,558 11,907 2,871,823

3. The independent registered public accounting firm for the current fiscal year was ratified based upon the following votes:

For Against Abstain Broker Non-Votes 47,042,349 145,645 13,755 -

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