On May 18, 2012, the Board of Directors approved a grant of 75,000 restricted shares of the Registrant's common stock, to vest upon the third anniversary of the date of grant, to Klaus Lindpaintner, the Registrant's Vice President and Chief Scientific Officer.

On May 15, 2012, the Registrant held its 2012 Annual Meeting of Stockholders. At the meeting, the stockholders voted on (1) the election of four directors and
(2) the ratification of the appointment of KPMG LLP as the Registrant's independent registered public accounting firm for 2012. The voting results on these proposals were as follows:

Proposal 1. Election of four directors to hold office until 2014.

       Nominee           Votes For    Withheld   Broker Non-Votes
C. Geoffrey Davis        10,392,812   252,644       6,808,190
Richard Van den Broek.   10,424,276   221,180       6,808,190
Stephen L. Waechter      10,392,012   253,444       6,808,190
Wayne P. Yetter          10,357,728   287,728       6,808,190

Proposal 2. Ratification of the appointment of KPMG LLP as the Registrant's independent registered public accounting firm for 2012.

Votes For Votes Against Abstentions Broker Non-Votes 17,357,967 76,834 18,845 -

On May 18, 2012, the Board of Directors appointed Steven R. Becker, a current member of the Board, to serve as Chairman of the Board of Directors. Thomas A. Bologna, the previous Chairman, continues to serve on the Board.