On May 8, 2012, TranS1 Inc. (the "Company") issued a press release to report its operating results for the first quarter ended March 31, 2012. The release is furnished herewith as Exhibit 99.1 and incorporated herein by this reference.

Also on May 8, 2012, following the issuance of the press release referred to above, the Company conducted a conference call to discuss its financial results for the first quarter ended March 31, 2012. A copy of the transcript of the conference call is furnished herewith as Exhibit 99.2 and incorporated herein by this reference.

The information in this Current Report on Form 8-K, including Exhibits 99.1 and 99.2, are being furnished pursuant to Item 2.02 and shall not be deemed "filed" for the purposes of Section 18 of the Securities Exchange Act of 1934, as amended, or otherwise subject to the liability of that section, nor shall they be deemed incorporated by reference in any filing under the Securities Act of 1933, as amended, except as shall be expressly set forth by specific reference in such a filing.

(d) Exhibits.

         Exhibit Number   Description

              99.1        Press release, dated May 8, 2012.

              99.2        Conference call transcript, dated May 8, 2012.