Item 1.01 Entry into a Material Definitive Agreement.

On February 22, 2012, NexMed (U.S.A.), Inc., a wholly-owned subsidiary of Apricus Biosciences, Inc. (the "Company"), entered into a Vitaros®Cream Clinical Supply Agreement (the "Supply Agreement") with Warner Chilcott UK Limited (together with its affiliates "WC").

Under the Supply Agreement, the Company will receive approximately $250,000 in exchange for the current ordered quantity of Vitaros®.