Item 1.01 Entry Into A Material Definitive Agreement.

On December 7, 2011, Puma Biotechnology, Inc., a Delaware corporation (the "Company"), entered into an Office Lease (the "Lease") with CA-10880 Wilshire Limited Partnership, a Delaware limited partnership, for approximately 13,254 rentable square feet of office space in the building located at 10880 Wilshire Boulevard, Los Angeles, California 90024 for use as the Company's headquarters. The initial term of the Lease is for seven years and is expected to commence on or about December 19, 2011. The base rent will be approximately $44,400 per month during the first year and will increase each year during the initial term, up to approximately $53,000 per month during the seventh year. In addition, the Company has an option to extend the Lease for an additional five-year term, which would commence upon the expiration of the initial term. In the event the Company elects to extend the Lease, the minimum monthly rent payable for the additional term will be determined according to the then-prevailing market rate.

The foregoing summary of the Lease does not purport to be complete and is qualified in its entirety by reference to the full text of the Lease, a copy of which is filed as Exhibit 10.1 to this Current Report on Form 8-K and incorporated herein by reference.

Item 9.01 Financial Statements and Exhibits.

(d) Exhibits.

10.1 Office Lease by and between Puma Biotechnology, Inc. and CA-10880 Wilshire Limited Partnership, executed on December 7, 2011

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